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Literature DB >> 21557625

Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.

Yikai Wang¹, Miguel Jimenez, Anders S Hansen, Eun-Ang Raiber, Stuart L Schreiber, Damian W Young.

Abstract

Introducing a silyl group at one of the internal olefin positions in diolefinic substrates results in E-selective olefin formation in macrocyclic ring-forming metathesis. The application of this method to a range of macrocyclic (E)-alkenylsiloxanes is described. Protodesilylation of alkenylsiloxane products yields novel Z-configured macrocycles.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2011 PMID： 21557625 PMCID： PMC5436309 DOI： 10.1021/ja202012s

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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