Establishment of a new human uterine cervical adenocarcinoma cell-line, siso, and its reactivity to anticancer reagents.

A human cell line, SiSo, was established from a patient afflicted with uterine cervical adenocarcinoma. The SiSo cell expresses MHC class I antigen, various kinds of adhesion molecules and tumor-associated antigens such as CA125, CEA and GA733. The secretion of CA125 antigen was markedly suppressed by anti-cancer reagents. However, their growth was not affected by any of the anti-cancer reagents tested, suggesting a discrepancy between inhibition of tumor growth and suppression of secretion of tumor-associated antigens after treatment with anti-cancer reagents. The SiSo cell line will provide a tool for investigation of uterine adenocarcinoma.