Acid controlled diastereoselectivity in asymmetric aldol reaction of cycloketones with aldehydes using enamine-based organocatalysts.

The example of syn-aldol reaction of cyclohexanone to aldehyde was demonstrated based on chiral diamine organocatalysts and it was realized either by increasing the molecular size of acid additives or by introducing a hydrogen-bond donor into acid additives. This journal is © The Royal Society of Chemistry 2011