| Literature DB >> 21555224 |
Yiran Wu1, Zheng Chen, Ying Liu, Lanlan Yu, Lu Zhou, Suijia Yang, Luhua Lai.
Abstract
A series of novel fused heterocycle methyl esters were designed and synthesized as human nonpancreatic secretory phospholipase A₂ (hnps-PLA₂) competitive inhibitors. Among the 22 synthesized compounds, 17 quinoline-4-methyl esters displayed hnps-PLA₂ inhibition activity in the in vitro bioassay. The IC₅₀ value for the best compound 3o was 1.5 μM. The structure-inhibition-activity relationships of the compounds were studied using molecular docking. CrownEntities:
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Year: 2011 PMID： 21555224 DOI： 10.1016/j.bmc.2011.04.039
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641