Literature DB >> 21555069

The many faces of tau.

Meaghan Morris1, Sumihiro Maeda, Keith Vossel, Lennart Mucke.   

Abstract

While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21555069      PMCID： PMC3319390          DOI： 10.1016/j.neuron.2011.04.009

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  197 in total

1.  Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model.

Authors:  Bin Zhang; Arpita Maiti; Sharon Shively; Fara Lakhani; Gaye McDonald-Jones; Jennifer Bruce; Edward B Lee; Sharon X Xie; Sonali Joyce; Chi Li; Philip M Toleikis; Virginia M-Y Lee; John Q Trojanowski
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-22       Impact factor: 11.205

2.  Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.

Authors:  Julie A Harris; Nino Devidze; Laure Verret; Kaitlyn Ho; Brian Halabisky; Myo T Thwin; Daniel Kim; Patricia Hamto; Iris Lo; Gui-Qiu Yu; Jorge J Palop; Eliezer Masliah; Lennart Mucke
Journal:  Neuron       Date:  2010-11-04       Impact factor: 17.173

Review 3.  Amyloid oligomers: formation and toxicity of Abeta oligomers.

Authors:  Masafumi Sakono; Tamotsu Zako
Journal:  FEBS J       Date:  2010-02-09       Impact factor: 5.542

4.  Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments.

Authors:  M Morishima-Kawashima; M Hasegawa; K Takio; M Suzuki; K Titani; Y Ihara
Journal:  Neuron       Date:  1993-06       Impact factor: 17.173

5.  Nuclear tau, a key player in neuronal DNA protection.

Authors:  Audrey Sultan; Fabrice Nesslany; Marie Violet; Séverine Bégard; Anne Loyens; Smail Talahari; Zeyni Mansuroglu; Daniel Marzin; Nicolas Sergeant; Sandrine Humez; Morvane Colin; Eliette Bonnefoy; Luc Buée; Marie-Christine Galas
Journal:  J Biol Chem       Date:  2010-12-03       Impact factor: 5.157

6.  Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

Authors:  Jean C Augustinack; Anja Schneider; Eva-Maria Mandelkow; Bradley T Hyman
Journal:  Acta Neuropathol       Date:  2002-01       Impact factor: 17.088

7.  U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy.

Authors:  Shigetsugu Hatakeyama; Masaki Matsumoto; Takumi Kamura; Miyuki Murayama; Du-Hua Chui; Emmanuel Planel; Ryosuke Takahashi; Keiichi I Nakayama; Akihiko Takashima
Journal:  J Neurochem       Date:  2004-10       Impact factor: 5.372

8.  Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.

Authors:  Jeannie Chin; Jorge J Palop; Gui-Qiu Yu; Nobuhiko Kojima; Eliezer Masliah; Lennart Mucke
Journal:  J Neurosci       Date:  2004-05-12       Impact factor: 6.167

9.  Molecular chaperone-mediated tau protein metabolism counteracts the formation of granular tau oligomers in human brain.

Authors:  N Sahara; S Maeda; Y Yoshiike; T Mizoroki; S Yamashita; M Murayama; J-M Park; Y Saito; S Murayama; A Takashima
Journal:  J Neurosci Res       Date:  2007-11-01       Impact factor: 4.164

10.  Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity.

Authors:  Dohoon Kim; Christopher L Frank; Matthew M Dobbin; Rachel K Tsunemoto; Weihong Tu; Peter L Peng; Ji-Song Guan; Byung-Hoon Lee; Lily Y Moy; Paola Giusti; Nisha Broodie; Ralph Mazitschek; Ivanna Delalle; Stephen J Haggarty; Rachael L Neve; Youming Lu; Li-Huei Tsai
Journal:  Neuron       Date:  2008-12-10       Impact factor: 17.173
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  346 in total

1.  Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease.

Authors:  Sophie Sokolow; Kristen M Henkins; Tina Bilousova; Bianca Gonzalez; Harry V Vinters; Carol A Miller; Lindsey Cornwell; Wayne W Poon; Karen H Gylys
Journal:  J Neurochem       Date:  2015-01-13       Impact factor: 5.372

Review 2.  Mouse models of Alzheimer's disease.

Authors:  Alicia M Hall; Erik D Roberson
Journal:  Brain Res Bull       Date:  2011-11-28       Impact factor: 4.077

3.  The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.

Authors:  Jean-Marie Sontag; Viyada Nunbhakdi-Craig; Charles L White; Shelley Halpain; Estelle Sontag
Journal:  J Biol Chem       Date:  2012-03-08       Impact factor: 5.157

Review 4.  Tau-targeted treatment strategies in Alzheimer's disease.

Authors:  Jürgen Götz; Arne Ittner; Lars M Ittner
Journal:  Br J Pharmacol       Date:  2012-03       Impact factor: 8.739

5.  Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.

Authors:  Donna M Barten; Patrizia Fanara; Cathy Andorfer; Nina Hoque; P Y Anne Wong; Kristofor H Husted; Gregory W Cadelina; Lynn B Decarr; Ling Yang; Victoria Liu; Chancy Fessler; Joan Protassio; Timothy Riff; Holly Turner; Christopher G Janus; Sethu Sankaranarayanan; Craig Polson; Jere E Meredith; Gemma Gray; Amanda Hanna; Richard E Olson; Soong-Hoon Kim; Gregory D Vite; Francis Y Lee; Charles F Albright
Journal:  J Neurosci       Date:  2012-05-23       Impact factor: 6.167

Review 6.  Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system.

Authors:  Nicholas M Kanaan; Gustavo F Pigino; Scott T Brady; Orly Lazarov; Lester I Binder; Gerardo A Morfini
Journal:  Exp Neurol       Date:  2012-06-19       Impact factor: 5.330

Review 7.  It's all about tau.

Authors:  Cheril Tapia-Rojas; Fabian Cabezas-Opazo; Carol A Deaton; Erick H Vergara; Gail V W Johnson; Rodrigo A Quintanilla
Journal:  Prog Neurobiol       Date:  2018-12-31       Impact factor: 11.685

Review 8.  Hyperphosphorylated tau is implicated in acquired epilepsy and neuropsychiatric comorbidities.

Authors:  Ping Zheng; Sandy R Shultz; Chris M Hovens; Dennis Velakoulis; Nigel C Jones; Terence J O'Brien
Journal:  Mol Neurobiol       Date:  2013-12-10       Impact factor: 5.590

9.  Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation.

Authors:  Chuanzhou Li; Jürgen Götz
Journal:  EMBO J       Date:  2017-09-01       Impact factor: 11.598

Review 10.  Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease.

Authors:  Tara E Tracy; Li Gan
Journal:  Curr Opin Neurobiol       Date:  2018-05-10       Impact factor: 6.627
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