OBJECTIVE: To evaluate the pathophysiologic changes in the inner ear during the course of severe cerebral malaria in an established animal model, C57 BL/6J mice. METHODS: This study aims to examine the hearing threshold, the histological changes and ICAM-1 expression in the murine cochlea. RESULTS: Four of seven mice showed an expected hearing loss of 20 dB or more. The light microscopy of the inner ear did not show any morphologic alterations. The immunohistochemical analysis for ICAM-1 showed intensive staining in the stria vascularis of sick animals and hardly any reaction in healthy controls. CONCLUSION: The up-regulation of ICAM-1 in the stria vascularis - generating the endocochlear potential - suggests its involvement in plasmodial infection.
OBJECTIVE: To evaluate the pathophysiologic changes in the inner ear during the course of severe cerebral malaria in an established animal model, C57 BL/6J mice. METHODS: This study aims to examine the hearing threshold, the histological changes and ICAM-1 expression in the murine cochlea. RESULTS: Four of seven mice showed an expected hearing loss of 20 dB or more. The light microscopy of the inner ear did not show any morphologic alterations. The immunohistochemical analysis for ICAM-1 showed intensive staining in the stria vascularis of sick animals and hardly any reaction in healthy controls. CONCLUSION: The up-regulation of ICAM-1 in the stria vascularis - generating the endocochlear potential - suggests its involvement in plasmodial infection.
Authors: Joachim Schmutzhard; Christian H Kositz; Rudolf Glueckert; Erich Schmutzhard; Annelies Schrott-Fischer; Peter Lackner Journal: Malar J Date: 2012-02-01 Impact factor: 2.979
Authors: Joachim Schmutzhard; Peter Lackner; Raimund Helbok; Helene Verena Hurth; Fabian Cedric Aregger; Veronika Muigg; Josua Kegele; Sebastian Bunk; Lukas Oberhammer; Natalie Fischer; Leyla Pinggera; Allan Otieno; Bernards Ogutu; Tsiri Agbenyega; Daniel Ansong; Ayola A Adegnika; Saadou Issifou; Patrick Zorowka; Sanjeev Krishna; Benjamin Mordmüller; Erich Schmutzhard; Peter Kremsner Journal: BMC Med Date: 2015-05-28 Impact factor: 8.775
Authors: Joachim Schmutzhard; Rudolf Glueckert; Christian Pritz; Michael J F Blumer; Mario Bitsche; Peter Lackner; Manfred Fille; Herbert Riechelmann; Matthias Harkamp; Thongrong Sitthisak; Annelies Schrott-Fischer Journal: Dis Model Mech Date: 2013-02-14 Impact factor: 5.758