BACKGROUND: Antimicrobial prophylaxis is commonly administered to patients undergoing left ventricular assist device (LVAD) surgeries to prevent infectious complications. However, optimal surgical infection prophylaxis (SIP) for LVAD surgeries is not well defined. METHODS: We conducted an electronic survey to characterize LVAD SIP used at different centers performing LVAD implantation. RESULTS: Responses were received from 23 of 85 centers (27%). Of 21 centers that provided usable data about their LVAD SIP regimens for nonpenicillin allergic patients, 42.9% reported using a four-drug regimen (three antibiotics plus fluconazole), 23.8% reported using a three-drug regimen (three antibiotics or two antibiotics plus fluconazole), 23.8% reported using a regimen of two antibiotics, and 9.5% reported using vancomycin alone. A similar pattern was observed among SIP regimens for penicillin-allergic patients. Criteria for discontinuation of SIP and use of decolonization strategies also varied widely across centers. CONCLUSIONS: Our results demonstrate wide variability in LVAD SIP regimens and underscore the lack of consensus regarding best practice.
BACKGROUND: Antimicrobial prophylaxis is commonly administered to patients undergoing left ventricular assist device (LVAD) surgeries to prevent infectious complications. However, optimal surgical infection prophylaxis (SIP) for LVAD surgeries is not well defined. METHODS: We conducted an electronic survey to characterize LVAD SIP used at different centers performing LVAD implantation. RESULTS: Responses were received from 23 of 85 centers (27%). Of 21 centers that provided usable data about their LVAD SIP regimens for nonpenicillinallergicpatients, 42.9% reported using a four-drug regimen (three antibiotics plus fluconazole), 23.8% reported using a three-drug regimen (three antibiotics or two antibiotics plus fluconazole), 23.8% reported using a regimen of two antibiotics, and 9.5% reported using vancomycin alone. A similar pattern was observed among SIP regimens for penicillin-allergicpatients. Criteria for discontinuation of SIP and use of decolonization strategies also varied widely across centers. CONCLUSIONS: Our results demonstrate wide variability in LVAD SIP regimens and underscore the lack of consensus regarding best practice.
Authors: Nana Aburjania; Brennan M Ertmer; Saira Farid; Melody Berg; Juhsien J C Nienaber; Vakhtang Tchantchaleishvili; John M Stulak; Larry M Baddour; Muhammad R Sohail Journal: ASAIO J Date: 2018 Nov/Dec Impact factor: 2.872
Authors: Jennifer Sherwin; Elizabeth Thompson; Kevin D Hill; Kevin Watt; Andrew J Lodge; Daniel Gonzalez; Christoph P Hornik Journal: Cardiol Young Date: 2018-07-11 Impact factor: 1.093
Authors: Radoslav Zinoviev; Christopher K Lippincott; Sara C Keller; Nisha A Gilotra Journal: Open Forum Infect Dis Date: 2020-04-17 Impact factor: 3.835
Authors: Evgenij V Potapov; Christiaan Antonides; Maria G Crespo-Leiro; Alain Combes; Gloria Färber; Margaret M Hannan; Marian Kukucka; Nicolaas de Jonge; Antonio Loforte; Lars H Lund; Paul Mohacsi; Michiel Morshuis; Ivan Netuka; Mustafa Özbaran; Federico Pappalardo; Anna Mara Scandroglio; Martin Schweiger; Steven Tsui; Daniel Zimpfer; Finn Gustafsson Journal: Eur J Cardiothorac Surg Date: 2019-08-01 Impact factor: 4.191
Authors: Yue Qu; David McGiffin; Christina Kure; Janelle McLean; Courtney Duncan; Anton Y Peleg Journal: Front Microbiol Date: 2020-11-23 Impact factor: 5.640