| Literature DB >> 21554346 |
N F Schulman1, G Sahana, T Iso-Touru, S D McKay, R D Schnabel, M S Lund, J F Taylor, J Virta, J H Vilkki.
Abstract
A whole-genome scan using single marker association was used to detect chromosome regions associated with seven female fertility traits in Finnish Ayrshire dairy cattle. The phenotypic data consisted of de-regressed estimated breeding values for 340 bulls which were estimated using a single trait model. Genotypes were obtained with the Illumina BovineSNP50 panel and a total of 35 630 informative, high-quality single nucleotide polymorphism (SNP) markers were used. The association analysis was performed using a mixed-model approach which fitted a fixed effect for each SNP and a random polygenic effect. We detected eleven genome-wide significant associations on eight different chromosomes. With at least chromosome-wise significance after Bonferroni correction, sixteen SNPs on nine chromosomes showed significant associations with one or more fertility traits. The results confirmed quantitative trait loci on three chromosomes (1, 2 and 20) for fertility traits previously reported for the same breed and one on chromosome four previously detected in Holstein cattle.Entities:
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Year: 2011 PMID： 21554346 DOI： 10.1111/j.1365-2052.2010.02149.x
Source DB: PubMed Journal: Anim Genet ISSN： 0268-9146 Impact factor: 3.169