Literature DB >> 21554262

Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk.

Dalemari Crowther-Swanepoel1, Maria Chiara Di Bernardo, Krzysztof Jamroziak, Lidia Karabon, Irena Frydecka, Silvia Deaglio, Giovanni D'Arena, Davide Rossi, Gianluca Gaidano, Bianca Olver, Amy Lloyd, Peter Broderick, Luca Laurenti, Zofia Szemraj-Rogucka, Tadeusz Robak, Daniel Catovsky, Richard S Houlston.   

Abstract

A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (P(combined) = 1·10 × 10(-7) and 1·30 × 10(-5) respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.
© 2011 Blackwell Publishing Ltd.

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Year:  2011        PMID： 21554262     DOI： 10.1111/j.1365-2141.2011.08706.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  9 in total

1.  Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.

Authors:  Susan L Slager; Christine F Skibola; Maria Chiara Di Bernardo; Lucia Conde; Peter Broderick; Shannon K McDonnell; Lynn R Goldin; Naomi Croft; Amy Holroyd; Shelley Harris; Jacques Riby; Daniel J Serie; Neil E Kay; Timothy G Call; Paige M Bracci; Eran Halperin; Mark C Lanasa; Julie M Cunningham; Jose F Leis; Vicki A Morrison; Logan G Spector; Celine M Vachon; Tait D Shanafelt; Sara S Strom; Nicola J Camp; J Brice Weinberg; Estella Matutes; Neil E Caporaso; Rachel Wade; Martin J S Dyer; Claire Dearden; James R Cerhan; Daniel Catovsky; Richard S Houlston
Journal:  Blood       Date:  2012-06-13       Impact factor: 22.113

2.  Common genetic variation contributes significantly to the risk of developing chronic lymphocytic leukemia.

Authors:  Maria Chiara Di Bernardo; Peter Broderick; Daniel Catovsky; Richard S Houlston
Journal:  Haematologica       Date:  2012-08-16       Impact factor: 9.941

3.  Single nucleotide polymorphisms and inherited risk of chronic lymphocytic leukemia among African Americans.

Authors:  Catherine C Coombs; Laura Z Rassenti; Lorenzo Falchi; Susan L Slager; Sara S Strom; Alessandra Ferrajoli; J Brice Weinberg; Thomas J Kipps; Mark C Lanasa
Journal:  Blood       Date:  2012-06-28       Impact factor: 22.113

Review 4.  Genomic approaches to chronic lymphocytic leukemia.

Authors:  Ma Reina Improgo; Jennifer R Brown
Journal:  Hematol Oncol Clin North Am       Date:  2013-04       Impact factor: 3.722

Review 5.  Genetic susceptibility to chronic lymphocytic leukemia.

Authors:  Susan L Slager; Neil E Caporaso; Silvia de Sanjose; Lynn R Goldin
Journal:  Semin Hematol       Date:  2013-10       Impact factor: 3.851

Review 6.  Associations of non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci.

Authors:  Sophia S Wang; Claire M Vajdic; Martha S Linet; Susan L Slager; Jenna Voutsinas; Alexandra Nieters; Silvia de Sanjose; Wendy Cozen; Graciela S Alarcón; Otoniel Martinez-Maza; Elizabeth E Brown; Paige M Bracci; Tracy Lightfoot; Jennifer Turner; Henrik Hjalgrim; John J Spinelli; Tongzhang Zheng; Lindsay M Morton; Brenda M Birmann; Christopher R Flowers; Ora Paltiel; Nikolaus Becker; Elizabeth A Holly; Eleanor Kane; Dennis Weisenburger; Marc Maynadie; Pierluigi Cocco; Lenka Foretova; Anthony Staines; Scott Davis; Richard Severson; James R Cerhan; Elizabeth C Breen; Qing Lan; Angela Brooks-Wilson; Anneclaire J De Roos; Martyn T Smith; Eve Roman; Paolo Boffetta; Anne Kricker; Yawei Zhang; Christine Skibola; Stephen J Chanock; Nathaniel Rothman; Yolanda Benavente; Patricia Hartge; Karin E Smedby
Journal:  Am J Epidemiol       Date:  2015-02-23       Impact factor: 5.363

7.  Post-GWAS functional characterization of susceptibility variants for chronic lymphocytic leukemia.

Authors:  Fenna C M Sillé; Reuben Thomas; Martyn T Smith; Lucia Conde; Christine F Skibola
Journal:  PLoS One       Date:  2012-01-03       Impact factor: 3.240

8.  Current understanding of lifestyle and environmental factors and risk of non-hodgkin lymphoma: an epidemiological update.

Authors:  Bryan A Bassig; Qing Lan; Nathaniel Rothman; Yawei Zhang; Tongzhang Zheng
Journal:  J Cancer Epidemiol       Date:  2012-09-12

9.  Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.

Authors:  Sonja I Berndt; Christine F Skibola; Vijai Joseph; Nicola J Camp; Alexandra Nieters; Zhaoming Wang; Wendy Cozen; Alain Monnereau; Sophia S Wang; Rachel S Kelly; Qing Lan; Lauren R Teras; Nilanjan Chatterjee; Charles C Chung; Meredith Yeager; Angela R Brooks-Wilson; Patricia Hartge; Mark P Purdue; Brenda M Birmann; Bruce K Armstrong; Pierluigi Cocco; Yawei Zhang; Gianluca Severi; Anne Zeleniuch-Jacquotte; Charles Lawrence; Laurie Burdette; Jeffrey Yuenger; Amy Hutchinson; Kevin B Jacobs; Timothy G Call; Tait D Shanafelt; Anne J Novak; Neil E Kay; Mark Liebow; Alice H Wang; Karin E Smedby; Hans-Olov Adami; Mads Melbye; Bengt Glimelius; Ellen T Chang; Martha Glenn; Karen Curtin; Lisa A Cannon-Albright; Brandt Jones; W Ryan Diver; Brian K Link; George J Weiner; Lucia Conde; Paige M Bracci; Jacques Riby; Elizabeth A Holly; Martyn T Smith; Rebecca D Jackson; Lesley F Tinker; Yolanda Benavente; Nikolaus Becker; Paolo Boffetta; Paul Brennan; Lenka Foretova; Marc Maynadie; James McKay; Anthony Staines; Kari G Rabe; Sara J Achenbach; Celine M Vachon; Lynn R Goldin; Sara S Strom; Mark C Lanasa; Logan G Spector; Jose F Leis; Julie M Cunningham; J Brice Weinberg; Vicki A Morrison; Neil E Caporaso; Aaron D Norman; Martha S Linet; Anneclaire J De Roos; Lindsay M Morton; Richard K Severson; Elio Riboli; Paolo Vineis; Rudolph Kaaks; Dimitrios Trichopoulos; Giovanna Masala; Elisabete Weiderpass; María-Dolores Chirlaque; Roel C H Vermeulen; Ruth C Travis; Graham G Giles; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Jacqueline Clavel; Tongzhang Zheng; Theodore R Holford; Kenneth Offit; Andrew Zelenetz; Robert J Klein; John J Spinelli; Kimberly A Bertrand; Francine Laden; Edward Giovannucci; Peter Kraft; Anne Kricker; Jenny Turner; Claire M Vajdic; Maria Grazia Ennas; Giovanni M Ferri; Lucia Miligi; Liming Liang; Joshua Sampson; Simon Crouch; Ju-Hyun Park; Kari E North; Angela Cox; John A Snowden; Josh Wright; Angel Carracedo; Carlos Lopez-Otin; Silvia Bea; Itziar Salaverria; David Martin-Garcia; Elias Campo; Joseph F Fraumeni; Silvia de Sanjose; Henrik Hjalgrim; James R Cerhan; Stephen J Chanock; Nathaniel Rothman; Susan L Slager
Journal:  Nat Genet       Date:  2013-06-16       Impact factor: 41.307
  9 in total

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