Literature DB >> 2155425

Murine interleukin 2 receptor beta chain: dysregulated gene expression in lymphoma line EL-4 caused by a promoter insertion.

T Kono1, T Doi, G Yamada, M Hatakeyama, S Minamoto, M Tsudo, M Miyasaka, T Miyata, T Taniguchi.   

Abstract

The functional, high-affinity interleukin 2 receptor (IL-2R) consists of at least two receptor components, IL-2R alpha (p55) and IL-2R beta (p70-75). The cDNA encoding the murine IL-2R beta has been isolated by using the previously cloned cDNA for human IL-2R beta as a probe. Analysis of the cDNA revealed that the murine IL-2R beta shows a marked homology with the human IL-2R beta and that it is also structurally related to other cytokine receptors such as erythropoietin receptor. The cDNA-directed murine IL-2R beta formed high-affinity IL-2R in conjunction with the endogenous IL-2R alpha in a murine pro-B-cell line and could transduce IL-2-induced growth signal. In mouse lymphoma line EL-4, the IL-2R beta gene was found to be rearranged by the insertion of the long terminal repeat sequence of an intracisternal A particle, giving rise to constitutive expression of the IL-2R beta mRNA.

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Year:  1990        PMID： 2155425      PMCID： PMC53572          DOI： 10.1073/pnas.87.5.1806

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  38 in total

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Authors:  M Sharon; R D Klausner; B R Cullen; R Chizzonite; W J Leonard
Journal:  Science       Date:  1986-11-14       Impact factor: 47.728

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Authors:  T Taniguchi; H Matsui; T Fujita; M Hatakeyama; N Kashima; A Fuse; J Hamuro; C Nishi-Takaoka; G Yamada
Journal:  Immunol Rev       Date:  1986-08       Impact factor: 12.988

Review 3.  The human interleukin-2 receptor.

Authors:  W C Greene; W J Leonard
Journal:  Annu Rev Immunol       Date:  1986       Impact factor: 28.527

4.  Serological analysis of cell surface antigens of tumors induced by murine leukemia virus.

Authors:  R B Herberman
Journal:  J Natl Cancer Inst       Date:  1972-01       Impact factor: 13.506

5.  Rearrangement of the oncogene c-mos in mouse myeloma NSI and hybridomas.

Authors:  J B Cohen; T Unger; G Rechavi; E Canaani; D Givol
Journal:  Nature       Date:  1983 Dec 22-1984 Jan 4       Impact factor: 49.962

6.  The structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes.

Authors:  T A Waldmann
Journal:  Science       Date:  1986-05-09       Impact factor: 47.728

7.  Regulation of human interleukin-2 gene: functional DNA sequences in the 5' flanking region for the gene expression in activated T lymphocytes.

Authors:  T Fujita; H Shibuya; T Ohashi; K Yamanishi; T Taniguchi
Journal:  Cell       Date:  1986-08-01       Impact factor: 41.582

8.  Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen.

Authors:  R J Robb; W C Greene; C M Rusk
Journal:  J Exp Med       Date:  1984-10-01       Impact factor: 14.307

9.  Reconstitution of functional receptor for human interleukin-2 in mouse cells.

Authors:  M Hatakeyama; S Minamoto; T Uchiyama; R R Hardy; G Yamada; T Taniguchi
Journal:  Nature       Date:  1985 Dec 5-11       Impact factor: 49.962

10.  Structure of the functional interleukin-2 receptor. Evidence for the association of human p55 and murine p75 molecules in a mouse T cell line.

Authors:  A Yamaguchi; T Ide; M Hatakeyama; T Doi; T Kono; T Uchiyama; K Kikuchi; T Taniguchi; T Uede
Journal:  Int Immunol       Date:  1989       Impact factor: 4.823
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  26 in total

1.  Human and murine IL2 receptors differentially respond to the human-IL2 component of immunocytokines.

Authors:  Zulmarie Perez Horta; Swetha Saseedhar; Alexander L Rakhmilevich; Lakeesha Carmichael; Jacquelyn A Hank; Margaret Boyden; Stephen D Gillies; Paul M Sondel
Journal:  Oncoimmunology       Date:  2018-05-07       Impact factor: 8.110

2.  Structural design and molecular evolution of a cytokine receptor superfamily.

Authors:  J F Bazan
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

3.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1990-05-25       Impact factor: 16.971

4.  Characterization of mpl cytoplasmic domain sequences required for myeloproliferative leukemia virus pathogenicity.

Authors:  L Bénit; G Courtois; M Charon; P Varlet; I Dusanter-Fourt; S Gisselbrecht
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

5.  Functional dissection of the cytoplasmic subregions of the IL-2 receptor betac chain in primary lymphocyte populations.

Authors:  H Fujii; K Ogasawara; H Otsuka; M Suzuki; K Yamamura; T Yokochi; T Miyazaki; H Suzuki; T W Mak; S Taki; T Taniguchi
Journal:  EMBO J       Date:  1998-11-16       Impact factor: 11.598

6.  Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

Authors:  N Kobayashi; T Kono; M Hatakeyama; Y Minami; T Miyazaki; R M Perlmutter; T Taniguchi
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205

7.  c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor beta chain.

Authors:  M Hatakeyama; A Kawahara; H Mori; H Shibuya; T Taniguchi
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205

8.  The acquisition of cytokine responsiveness by murine B cells: a role for antigen and IL-5 in the induction of IL-2 receptors.

Authors:  J Poudrier; T Owens
Journal:  Immunology       Date:  1994-03       Impact factor: 7.397

9.  Intracisternal A-type particle-mediated activations of cytokine genes in a murine myelomonocytic leukemia: generation of functional cytokine mRNAs by retroviral splicing events.

Authors:  K B Leslie; F Lee; J W Schrader
Journal:  Mol Cell Biol       Date:  1991-11       Impact factor: 4.272

10.  Unregulated expression of the erythropoietin receptor gene caused by insertion of spleen focus-forming virus long terminal repeat in a murine erythroleukemia cell line.

Authors:  M Hino; A Tojo; Y Misawa; H Morii; F Takaku; M Shibuya
Journal:  Mol Cell Biol       Date:  1991-11       Impact factor: 4.272
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