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Literature DB >> 21550842

Sustained elite suppression of replication competent HIV-1 in a patient treated with rituximab based chemotherapy.

Stephanie Gaillard¹, Jason B Dinoso, Julia A Marsh, Amy E DeZern, Karen A O'Connell, Adam M Spivak, Karla Alwood, Christine M Durand, Richard F Ambinder, Joel N Blankson.

Abstract

The mechanism of elite control of HIV-1 replication is not fully understood. While immunosuppression due to rituximab based chemotherapy has been associated with increased replication of HBV, CMV, and HIV-1, control of replication-competent HIV-1 was maintained in an elite controller/suppressor treated with a regimen that included vincristine, cyclophosphamide, prednisone, four rounds of plasmapheresis and ten cycles of rituximab. The data suggests that de-novo antibody responses do not play a significant role in the control of viral replication in these patients.

Entities: Chemical Disease Gene Species

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Year: 2011 PMID： 21550842 PMCID： PMC3117974 DOI： 10.1016/j.jcv.2011.04.002

Source DB: PubMed Journal: J Clin Virol ISSN： 1386-6532 Impact factor: 3.168

19 in total

1. HIV-1 continues to replicate and evolve in patients with natural control of HIV infection.

Authors: Helene Mens; Mary Kearney; Ann Wiegand; Wei Shao; Kristian Schønning; Jan Gerstoft; Niels Obel; Frank Maldarelli; John W Mellors; Thomas Benfield; John M Coffin
Journal: J Virol Date: 2010-10-06 Impact factor: 5.103

2. Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapy.

Authors: Justin R Bailey; Kara G Lassen; Hung-Chih Yang; Thomas C Quinn; Stuart C Ray; Joel N Blankson; Robert F Siliciano
Journal: J Virol Date: 2006-05 Impact factor: 5.103

3. Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis.

Authors: B Ramratnam; S Bonhoeffer; J Binley; A Hurley; L Zhang; J E Mittler; M Markowitz; J P Moore; A S Perelson; D D Ho
Journal: Lancet Date: 1999-11-20 Impact factor: 79.321

4. Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.

Authors: Joel N Blankson; Justin R Bailey; Seema Thayil; Hung-Chih Yang; Kara Lassen; Jun Lai; Shiv K Gandhi; Janet D Siliciano; Thomas M Williams; Robert F Siliciano
Journal: J Virol Date: 2006-12-06 Impact factor: 5.103

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Journal: Nature Date: 2003-03-20 Impact factor: 49.962

6. Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection.

Authors: R A Kaslow; M Carrington; R Apple; L Park; A Muñoz; A J Saah; J J Goedert; C Winkler; S J O'Brien; C Rinaldo; R Detels; W Blattner; J Phair; H Erlich; D L Mann
Journal: Nat Med Date: 1996-04 Impact factor: 53.440

7. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients.

Authors: N J Deacon; A Tsykin; A Solomon; K Smith; M Ludford-Menting; D J Hooker; D A McPhee; A L Greenway; A Ellett; C Chatfield; V A Lawson; S Crowe; A Maerz; S Sonza; J Learmont; J S Sullivan; A Cunningham; D Dwyer; D Dowton; J Mills
Journal: Science Date: 1995-11-10 Impact factor: 47.728

8. B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection.

Authors: Kuan-Hsiang G Huang; David Bonsall; Aris Katzourakis; Emma C Thomson; Sarah J Fidler; Janice Main; David Muir; Jonathan N Weber; Alexander J Frater; Rodney E Phillips; Oliver G Pybus; Philip J R Goulder; Myra O McClure; Graham S Cooke; Paul Klenerman
Journal: Nat Commun Date: 2010-10-19 Impact factor: 14.919

9. Evolution of the HIV-1 nef gene in HLA-B*57 positive elite suppressors.

Authors: Maria Salgado; Timothy P Brennan; Karen A O'Connell; Justin R Bailey; Stuart C Ray; Robert F Siliciano; Joel N Blankson
Journal: Retrovirology Date: 2010-11-08 Impact factor: 4.602

10. Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART.

Authors: Erin H Graf; Angela M Mexas; Jianqing J Yu; Farida Shaheen; Megan K Liszewski; Michele Di Mascio; Stephen A Migueles; Mark Connors; Una O'Doherty
Journal: PLoS Pathog Date: 2011-02-24 Impact factor: 6.823

8 in total

1. HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice.

Authors: Maria Salgado; Michael D Swanson; Christopher W Pohlmeyer; Robert W Buckheit; Jin Wu; Nancie M Archin; Thomas M Williams; David M Margolis; Robert F Siliciano; J Victor Garcia; Joel N Blankson
Journal: J Virol Date: 2014-01-03 Impact factor: 5.103

Review 2. Developing strategies for HIV-1 eradication.

Authors: Christine M Durand; Joel N Blankson; Robert F Siliciano
Journal: Trends Immunol Date: 2012-08-03 Impact factor: 16.687

3. Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs.

Authors: Robert W Buckheit; Tracy G Allen; Angela Alme; Maria Salgado; Karen A O'Connell; Sarah Huculak; Oluwaseun Falade-Nwulia; Thomas M Williams; Joel E Gallant; Robert F Siliciano; Joel N Blankson
Journal: Nat Commun Date: 2012-03-06 Impact factor: 14.919