Literature DB >> 215508

Localization of a gene for human alpha-galactosidase B (= n-acetyl-alpha-d-galactosaminidase) on chromosome 22.

P G de Groot, A Westerveld, P Meera Khan, J M Tager.   

Abstract

The localization of the structural gene for human alpha-galactosidase B (= N-acetyl-alpha-galactosaminidase) was investigated by means of man-Chinese hamster and man-mouse somatic cell hybrids. The hybrid clones were analyzed for chromosomes and for a large number of known enzyme markers. The lysates of the hybrid cells were treated with Sepharose-coupled antihuman alpha-galactosidase B and the activity of the adsorbed enzyme was measured on the Sepharose beads as N-acetyl-alpha-galactosaminidase. The results show that the structural gene for human alpha-galactosidase B is situated on chromosome 22, and that there is no structural relationship between human alpha-galactosidase A and human alpha-galactosidase B.

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Year:  1978        PMID： 215508     DOI： 10.1007/bf00394295

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  24 in total

1.  Assignment of human genes: beta-glucuronidase to chromosome 7, adenylate kinase-1 to 9, a second enzyme with enolase activity to 12, and mitochondrial IDH to 15.

Authors:  K H Grzeschik
Journal:  Birth Defects Orig Artic Ser       Date:  1976

2.  Variability of -galactosidase A and B in different tissues of man.

Authors:  E Beutler; E Guinto; W Kuhl
Journal:  Am J Hum Genet       Date:  1973-01       Impact factor: 11.025

3.  X-linkage of human -galactosidase.

Authors:  K H Grzeschik; A M Grzeschik; S Banhof; G Romeo; M Siniscalco; H van Someren; P Meera Khan; A Westerveld; D Bootsma
Journal:  Nat New Biol       Date:  1972-11-08

4.  Relationship between human alpha-galactosidase isozymes.

Authors:  E Beutler; W Kuhl
Journal:  Nat New Biol       Date:  1972-10-18

5.  Purification and properties of human alpha-galactosidases.

Authors:  E Beutler; W Kuhl
Journal:  J Biol Chem       Date:  1972-11-25       Impact factor: 5.157

6.  Assignment of the AK1:Np:ABO linkage group to human chromosome 9.

Authors:  A Westerveld; A P Jongsma; P Meera Khan; H van Someren; D Bootsma
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

7.  A new immunochemical method for the quantitative measurement of specific gene products in man-rodent somatic cell hybrids.

Authors:  P G de Groot; M N Hamers; A Westerveld; A W Schram; P Meera Khan; J M Tager
Journal:  Hum Genet       Date:  1978-11-16       Impact factor: 4.132

8.  Regional localization of a beta-galactosidase locus on human chromosome 22.

Authors:  J De Wit; H L Hoeksema; D Halley; A Hagemeijer; D Bootsma; A Westerveld
Journal:  Somatic Cell Genet       Date:  1977-07

9.  Loss of human genetic markers in man--Chinese hamster somatic cell hybrids.

Authors:  A Westerveld; R P Visser; P Meera Khan; D Bootsma
Journal:  Nat New Biol       Date:  1971-11-03

10.  Investigation of the alpha-galactosidase deficiency in Fabry's disease using antibodies against the purified enzyme.

Authors:  P J Rietra; J L Molenaar; M N Hamers; J M Tager; P Borst
Journal:  Eur J Biochem       Date:  1974-07-01
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  4 in total

Review 1.  Human chromosome 22.

Authors:  J C Kaplan; A Aurias; C Julier; M Prieur; M F Szajnert
Journal:  J Med Genet       Date:  1987-02       Impact factor: 6.318

2.  A new immunochemical method for the quantitative measurement of specific gene products in man-rodent somatic cell hybrids.

Authors:  P G de Groot; M N Hamers; A Westerveld; A W Schram; P Meera Khan; J M Tager
Journal:  Hum Genet       Date:  1978-11-16       Impact factor: 4.132

3.  alpha-N-acetylgalactosaminidase deficiency, a new lysosomal storage disorder.

Authors:  O P van Diggelen; D Schindler; R Willemsen; M Boer; W J Kleijer; J G Huijmans; W Blom; H Galjaard
Journal:  J Inherit Metab Dis       Date:  1988       Impact factor: 4.982

Review 4.  Fabry Disease: Molecular Basis, Pathophysiology, Diagnostics and Potential Therapeutic Directions.

Authors:  Ken Kok; Kimberley C Zwiers; Rolf G Boot; Hermen S Overkleeft; Johannes M F G Aerts; Marta Artola
Journal:  Biomolecules       Date:  2021-02-12
  4 in total

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