| Literature DB >> 21550698 |
Hong Yin1, Weiping Zhu, Yufang Xu, Min Dai, Xuhong Qian, Yuanli Li, Jianwen Liu.
Abstract
A series of novel aliphatic N-oxide of naphthalimides (A1-A5) were designed and prepared. The N-O group was firstly introduced into the amine side chain tailed to planar naphthalimide chromophore as hypoxic bioreductive marker. Fluorescence image analysis showed that the compounds could be used as potential markers for hypoxic cells (V79) in vitro especially for A1 with 17 times hypoxic-oxic fluorescence differential, which was probably due to the bis-bioreduction mechanism.Entities:
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Year: 2011 PMID： 21550698 DOI： 10.1016/j.ejmech.2011.04.040
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514