G Querques1, D Kuhn, N Massamba, N Leveziel, L Querques, E H Souied. 1. Service d'ophtalmologie, centre hospitalier intercommunal de Créteil, université de Paris-XII, 40, avenue de Verdun, 94000 Créteil, France. giuseppe.querques@hotmail.it
Abstract
PURPOSE: To report the angiographic and optical coherence tomography (OCT) features of isolated "perifoveal exudative vascular anomalous complex (PEVAC)", a peculiar clinical entity. METHODS: A complete ophthalmologic examination was performed in two patients (a 82-year old woman [case 1]; a 52-year old man [case 2]) that were referred to our department for unilateral blurred vision. RESULTS: In both cases, fundus examination of the right eye showed a perifoveal isolated large aneurismal change, accompanied by small hemorrhages, intraretinal exudation, and small hard exudates accumulation. Both FA and ICGA revealed the absence of any other retinal or choroidal vascular abnormality associated. OCT showed a round hyperreflective lesion in correspondence of the perifoveal vascular anomalous complex, surrounded by intraretinal cystic spaces. In case 2, the lesion remained unchanged despite 3 monthly intravitreal injections of ranibizumab. CONCLUSION: PEVAC may develop in absence of capillary ischemia or inflammation, probably due to progressive retinal endothelial cell degeneration. This could explain the unresponsiveness to anti-VEGF treatments.
PURPOSE: To report the angiographic and optical coherence tomography (OCT) features of isolated "perifoveal exudative vascular anomalous complex (PEVAC)", a peculiar clinical entity. METHODS: A complete ophthalmologic examination was performed in two patients (a 82-year old woman [case 1]; a 52-year old man [case 2]) that were referred to our department for unilateral blurred vision. RESULTS: In both cases, fundus examination of the right eye showed a perifoveal isolated large aneurismal change, accompanied by small hemorrhages, intraretinal exudation, and small hard exudates accumulation. Both FA and ICGA revealed the absence of any other retinal or choroidal vascular abnormality associated. OCT showed a round hyperreflective lesion in correspondence of the perifoveal vascular anomalous complex, surrounded by intraretinal cystic spaces. In case 2, the lesion remained unchanged despite 3 monthly intravitreal injections of ranibizumab. CONCLUSION: PEVAC may develop in absence of capillary ischemia or inflammation, probably due to progressive retinal endothelial cell degeneration. This could explain the unresponsiveness to anti-VEGF treatments.
Authors: Jakob Siedlecki; Efstathios Vounotrypidis; Denise Vogt; Armin Wolf; Siegfried G Priglinger; Ricarda G Schumann Journal: Am J Ophthalmol Case Rep Date: 2019-04-04
Authors: José Ignacio Fernández-Vigo; Bárbara Burgos-Blasco; Rosa Dolz-Marco; María Jiménez-Santos; Lorenzo López-Guajardo; Juan Donate-López Journal: Am J Ophthalmol Case Rep Date: 2020-04-21
Authors: Lisette M Smid; Jennifer S N Verhoekx; José P Martinez Ciriano; Koenraad A Vermeer; Suzanne Yzer Journal: Acta Ophthalmol Date: 2020-11-19 Impact factor: 3.761
Authors: Nabil Herda; Oudy Semoun; Mayer Srour; Francesca Amoroso; May Baker; Vittorio Capuano; Donato Colantuono; Salomon Y Cohen; Giuseppe Querques; Eric H Souied Journal: Am J Ophthalmol Case Rep Date: 2022-08-28