Literature DB >> 2154975

Expression of retinoic acid receptor genes and the ligand-binding selectivity of retinoic acid receptors (RAR's).

Y Hashimoto1, H Kagechika, K Shudo.   

Abstract

Retinoids of a structurally new type, 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenylcarbamoyl)benzoic acid (Am80) and (E)-4-[3-(3,5-di-tert-butylphenyl)-3-oxo-1-propenyl]-benzoic acid (Ch55), were used for the investigation of retinoid receptors in some human cell lines. Previously, using these retinoids, we have established that HL-60 cells possess two retinoid receptors, RAR-alpha and RAR-beta. In this paper, we report coexpression of RAR-alpha- and RAR-beta-genes established by Northern analysis. Further, the binding selectivity of the RAR products toward all-trans-retinoic acid (RA), Am80 and Ch55 was studied by filter binding assay. The affinity of the ligands toward RAR-alpha decreased in the order of Ch55 greater than RA greater than Am80. The affinity of the ligands toward RAR-beta decreased in the order of Ch55 greater than Am80 greater than RA.

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Year:  1990        PMID： 2154975     DOI： 10.1016/0006-291x(90)91007-f

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  20 in total

1.  Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RAR beta 2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts.

Authors:  R Taneja; B Roy; J L Plassat; C F Zusi; J Ostrowski; P R Reczek; P Chambon
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

Review 2.  Strategies to generate functionally normal neutrophils to reduce infection and infection-related mortality in cancer chemotherapy.

Authors:  Hisham Abdel-Azim; Weili Sun; Lingtao Wu
Journal:  Pharmacol Ther       Date:  2019-08-27       Impact factor: 12.310

3.  Synthesis of [(11)C]Am80 via Novel Pd(0)-Mediated Rapid [(11)C]Carbonylation Using Arylboronate and [(11)C]Carbon Monoxide.

Authors:  Misato Takashima-Hirano; Hideki Ishii; Masaaki Suzuki
Journal:  ACS Med Chem Lett       Date:  2012-08-16       Impact factor: 4.345

4.  An essential set of basic DNA response elements is required for receptor-dependent transcription of the lecithin:retinol acyltransferase (Lrat) gene.

Authors:  Reza Zolfaghari; A Catharine Ross
Journal:  Arch Biochem Biophys       Date:  2009-08-08       Impact factor: 4.013

5.  All-trans-retinoic acid and Erk1/2 signaling synergistically regulate the expression of CD300B in human monocytic cells.

Authors:  Yong Wu; Qiuyan Chen; Tongkun Pai; A Catharine Ross
Journal:  Cell Immunol       Date:  2011-03-29       Impact factor: 4.868

6.  Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro and in a neutropenic mouse model.

Authors:  Wanjing Ding; Hiroyuki Shimada; Lin Li; Rahul Mittal; Xiaokun Zhang; Koichi Shudo; Qiaojun He; Nemani V Prasadarao; Lingtao Wu
Journal:  Blood       Date:  2012-12-13       Impact factor: 22.113

7.  All-trans-retinol is a ligand for the retinoic acid receptors.

Authors:  J J Repa; K K Hanson; M Clagett-Dame
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205

8.  Retinoic acid-induced down-regulation of the interleukin-2 promoter via cis-regulatory sequences containing an octamer motif.

Authors:  M P Felli; A Vacca; D Meco; I Screpanti; A R Farina; M Maroder; S Martinotti; E Petrangeli; L Frati; A Gulino
Journal:  Mol Cell Biol       Date:  1991-09       Impact factor: 4.272

9.  Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung.

Authors:  Lili Wu; A Catharine Ross
Journal:  J Lipid Res       Date:  2009-08-20       Impact factor: 5.922

10.  Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand.

Authors:  B Roy; R Taneja; P Chambon
Journal:  Mol Cell Biol       Date:  1995-12       Impact factor: 4.272
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