| Literature DB >> 21549594 |
Mingzhang Gao1, Christian M Lola, Min Wang, Kathy D Miller, George W Sledge, Qi-Huang Zheng.
Abstract
Vandetanib (ZD6474) and its chlorine analogue chloro-Vandetanib are potent and selective vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors with low nanomolar IC(50) values. [(11)C]Vandetanib and [(11)C]chloro-Vandetanib, new potential PET agents for imaging of VEGFR in cancer, were first designed, synthesized and labeled at nitrogen and oxygen positions from their corresponding N- and O-des-methylated precursors, in 40-50% decay corrected radiochemical yield and 370-555GBq/μmol specific activity at end of bombardment (EOB).Entities:
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Year: 2011 PMID： 21549594 DOI： 10.1016/j.bmcl.2011.04.049
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823