Anil Kumar Danda1, Poornima Ravi. 1. Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha University, Chennai, India. anilomfs@gmail.com
Abstract
PURPOSE: To conduct a systematic review of published clinical trials on the effectiveness of extended postoperative antibiotics in orthognathic surgery. MATERIALS AND METHODS: Electronic databases were searched for randomized clinical trials. Data from relevant articles were extracted and assessed. The primary outcome variable was surgical site infection. Extracted data were analyzed using a meta-analytical program with a random effects model. RESULTS: In total 532 patients were assessed in 8 clinical trials. Wound infection occurred in 30 of 268 patients in the short-term prophylaxis group (frequency, 11.2%) and in 10 of 264 patients in the extended-term group (frequency, 3.8%). Extended antibiotic therapy was more effective in decreasing the risk of postoperative wound infection (odds ratio, 3.2; number needed to treat, 13.5). CONCLUSION: Extended postoperative antibiotic treatment does have a place in decreasing the risk of postoperative wound infection in orthognathic surgery. More trials are needed to standardize a proper regimen.
PURPOSE: To conduct a systematic review of published clinical trials on the effectiveness of extended postoperative antibiotics in orthognathic surgery. MATERIALS AND METHODS: Electronic databases were searched for randomized clinical trials. Data from relevant articles were extracted and assessed. The primary outcome variable was surgical site infection. Extracted data were analyzed using a meta-analytical program with a random effects model. RESULTS: In total 532 patients were assessed in 8 clinical trials. Wound infection occurred in 30 of 268 patients in the short-term prophylaxis group (frequency, 11.2%) and in 10 of 264 patients in the extended-term group (frequency, 3.8%). Extended antibiotic therapy was more effective in decreasing the risk of postoperative wound infection (odds ratio, 3.2; number needed to treat, 13.5). CONCLUSION: Extended postoperative antibiotic treatment does have a place in decreasing the risk of postoperative wound infection in orthognathic surgery. More trials are needed to standardize a proper regimen.
Authors: Marco Friscia; Carolina Sbordone; Marzia Petrocelli; Luigi Angelo Vaira; Federica Attanasi; Francesco Maria Cassandro; Mariano Paternoster; Giorgio Iaconetta; Luigi Califano Journal: Oral Maxillofac Surg Date: 2017-03-02