Literature DB >> 21549323

The tragedy of translation: the case of "first use" in human embryonic stem cell research.

Jan Helge Solbakk1, Laurie Zoloth.   

Abstract

Who should go first in phase-I human trials when neither risks nor benefits can be estimated? By assessing concerns raised by Bretzner et al. (2011), we highlight a tragic dimension underlying all such trials. We discuss strategies to avoid the pitfalls of ethical hubris by promoting fidelity and trust.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID: 21549323     DOI: 10.1016/j.stem.2011.04.009

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN: 1875-9777            Impact factor:   24.633


  10 in total

1.  Ethical issues in nanomedicine: Tempest in a teapot?

Authors:  Irit Allon; Ahmi Ben-Yehudah; Raz Dekel; Jan-Helge Solbakk; Klaus-Michael Weltring; Gil Siegal
Journal:  Med Health Care Philos       Date:  2017-03

2.  One Size Fits All?: Ethical Considerations for Examining Efficacy in First-in-Human Pluripotent Stem Cell Studies.

Authors:  Michelle Gjl Habets; Johannes Jm van Delden; Sophie L Niemansburg; Harold L Atkins; Annelien L Bredenoord
Journal:  Mol Ther       Date:  2016-12       Impact factor: 11.454

Review 3.  Human pluripotent stem cells: Towards therapeutic development for the treatment of lifestyle diseases.

Authors:  Miwako Nishio; Masako Nakahara; Akira Yuo; Kumiko Saeki
Journal:  World J Stem Cells       Date:  2016-02-26       Impact factor: 5.326

Review 4.  Adapting Preclinical Benchmarks for First-in-Human Trials of Human Embryonic Stem Cell-Based Therapies.

Authors:  Gaia Barazzetti; Samia A Hurst; Alexandre Mauron
Journal:  Stem Cells Transl Med       Date:  2016-06-22       Impact factor: 6.940

Review 5.  A theoretical framework for early human studies: uncertainty, intervention ensembles, and boundaries.

Authors:  Jonathan Kimmelman
Journal:  Trials       Date:  2012-09-22       Impact factor: 2.279

Review 6.  What is the potential of oligodendrocyte progenitor cells to successfully treat human spinal cord injury?

Authors:  Robert A Watson; Trevor M Yeung
Journal:  BMC Neurol       Date:  2011-09-23       Impact factor: 2.474

7.  Current stem cell treatments for spinal cord injury.

Authors:  R Vawda; J Wilcox; Mg Fehlings
Journal:  Indian J Orthop       Date:  2012-01       Impact factor: 1.251

Review 8.  Cellular treatments for spinal cord injury: the time is right for clinical trials.

Authors:  Michael G Fehlings; Reaz Vawda
Journal:  Neurotherapeutics       Date:  2011-10       Impact factor: 7.620

Review 9.  Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges.

Authors:  Stuart I Jenkins; Humphrey H P Yiu; Matthew J Rosseinsky; Divya M Chari
Journal:  Mol Cell Ther       Date:  2014-07-28

Review 10.  Challenges to the clinical application of pluripotent stem cells: towards genomic and functional stability.

Authors:  Xuemei Fu; Yang Xu
Journal:  Genome Med       Date:  2012-06-28       Impact factor: 11.117

  10 in total

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