Literature DB >> 2154831

Clinical nerve reconstruction with a bioabsorbable polyglycolic acid tube.

S E Mackinnon1, A L Dellon.   

Abstract

Microneurosurgical techniques to reconstruct nerve gaps with nerve grafts frequently fail to achieve excellent functional results and create donor-site morbidity. In the present study, 15 patients had gaps of 0.5 to 3.0 cm (mean 1.7 cm) in digital nerves reconstructed by one surgeon with a bioabsorbable polyglycolic acid (PGA) tube. A final evaluation of sensibility was done by a second surgeon at a mean postoperative interval of 22.4 months (range 11 to 32 months). These were all secondary reconstructions. The evaluation included a digital nerve block with local anesthetic for the intact (not reconstructed) digital nerve. Excellent functional sensation (moving two-point discrimination less than or equal to 3 mm and/or static two-point discrimination less than or equal to 6 mm) was present in 33 percent and good functional sensation (moving two-point discrimination of 4 to 7 mm and/or static two-point discrimination of 7 to 15 mm) in 53 percent of the digital nerve reconstructions. One patient with poor sensory recovery and one with no recovery were judged as functional failures (14 percent). Absence of pain at the site of reconstruction was judged by the patient to be excellent in 40 percent, good in 33 percent, and poor in 27 percent. We conclude that reconstruction of nerve gaps of up to 3.0 cm with a bioabsorbable PGA tube gives clinical results at least comparable to the classic nerve graft technique while avoiding donor-site morbidity.

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Year:  1990        PMID: 2154831     DOI: 10.1097/00006534-199003000-00015

Source DB:  PubMed          Journal:  Plast Reconstr Surg        ISSN: 0032-1052            Impact factor:   4.730


  53 in total

1.  Synthetic collagen fibers coated with a synthetic peptide containing the YIGSR sequence of laminin to promote peripheral nerve regeneration in vivo.

Authors:  S Itoh; K Takakuda; H Samejima; T Ohta; K Shinomiya; S Ichinose
Journal:  J Mater Sci Mater Med       Date:  1999-03       Impact factor: 3.896

Review 2.  Review: peripheral nerve regeneration using non-tubular alginate gel crosslinked with covalent bonds.

Authors:  Tadashi Hashimoto; Yoshihisa Suzuki; Kyoko Suzuki; Toshihide Nakashima; Masao Tanihara; Chizuka Ide
Journal:  J Mater Sci Mater Med       Date:  2005-06       Impact factor: 3.896

3.  Limitations of conduits in peripheral nerve repairs.

Authors:  Amy M Moore; Rahul Kasukurthi; Christina K Magill; H Francis Farhadi; Gregory H Borschel; Susan E Mackinnon
Journal:  Hand (N Y)       Date:  2009-01-10

Review 4.  Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction.

Authors:  Damien P Kuffler
Journal:  Mol Neurobiol       Date:  2015-06-06       Impact factor: 5.590

5.  Effect of surface pore structure of nerve guide conduit on peripheral nerve regeneration.

Authors:  Se Heang Oh; Jin Rae Kim; Gu Birm Kwon; Uk Namgung; Kyu Sang Song; Jin Ho Lee
Journal:  Tissue Eng Part C Methods       Date:  2012-09-13       Impact factor: 3.056

6.  Engineering bi-layer nanofibrous conduits for peripheral nerve regeneration.

Authors:  Yiqian Zhu; Aijun Wang; Shyam Patel; Kyle Kurpinski; Edward Diao; Xuan Bao; George Kwong; William L Young; Song Li
Journal:  Tissue Eng Part C Methods       Date:  2011-04-18       Impact factor: 3.056

Review 7.  Biomaterials for the development of peripheral nerve guidance conduits.

Authors:  Alexander R Nectow; Kacey G Marra; David L Kaplan
Journal:  Tissue Eng Part B Rev       Date:  2011-09-23       Impact factor: 6.389

Review 8.  Clinical outcomes for Conduits and Scaffolds in peripheral nerve repair.

Authors:  David J Gerth; Jun Tashiro; Seth R Thaller
Journal:  World J Clin Cases       Date:  2015-02-16       Impact factor: 1.337

9.  Distal Inside-Out Epineural Sliding Technique to Repair Segmental Nerve Defects.

Authors:  Toni Luokkala; Jorma Ryhänen; Juha Näpänkangas; Teemu V Karjalainen
Journal:  Hand (N Y)       Date:  2016-02-05

10.  Functional recovery after implantation of artificial nerve grafts in the rat- a systematic review.

Authors:  Nektarios Sinis; Armin Kraus; Nikolaos Tselis; Max Haerle; Frank Werdin; Hans-Eberhard Schaller
Journal:  J Brachial Plex Peripher Nerve Inj       Date:  2009-10-25
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