Literature DB >> 2154725

Activation of the glycine site in the NMDA receptor is necessary for the induction of LTP.

Z I Bashir1, B Tam, G L Collingridge.   

Abstract

The effects of 7-chlorokynurenate (7-C1KY) were examined on N-methyl-D-aspartate (NMDA) receptor-mediated synaptic mechanisms in the CA1 region of rat hippocampal slices. 7-C1KY depressed both the NMDA receptor-mediated component of synaptic transmission recorded in Mg2(+)-free medium and the induction of long-term potentiation (LTP) in Mg2(+)-containing medium. Both of these effects were reversed by D-serine, suggesting that the action of 7-C1KY was at the allosteric glycine site on the NMDA receptor.

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Year:  1990        PMID： 2154725     DOI： 10.1016/0304-3940(90)90651-o

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  16 in total

1.  Sleep deprivation-induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampus.

Authors:  Carmel M McDermott; Mattie N Hardy; Nicolas G Bazan; Jeffrey C Magee
Journal:  J Physiol       Date:  2005-12-01       Impact factor: 5.182

2.  Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse.

Authors:  P Saransaari; S S Oja
Journal:  Neurochem Res       Date:  2001-07       Impact factor: 3.996

3.  Role of glycine receptors in glycine-induced LTD in hippocampal CA1 pyramidal neurons.

Authors:  Rong-Qing Chen; Shan-Hui Wang; Wen Yao; Jing-Jing Wang; Fang Ji; Jing-Zhi Yan; Si-Qiang Ren; Zheng Chen; Su-Yi Liu; Wei Lu
Journal:  Neuropsychopharmacology       Date:  2011-05-18       Impact factor: 7.853

4.  Sodium-dependent release of exogenous glycine from preloaded rat hippocampal synaptosomes.

Authors:  A Galli; F Mori; M Bargellini; L Coppini
Journal:  J Neural Transm Gen Sect       Date:  1993

5.  Abnormally persistent latent inhibition induced by MK801 is reversed by risperidone and by positive modulators of NMDA receptor function: differential efficacy depending on the stage of the task at which they are administered.

Authors:  I Gaisler-Salomon; L Diamant; C Rubin; I Weiner
Journal:  Psychopharmacology (Berl)       Date:  2007-10-11       Impact factor: 4.530

6.  Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy.

Authors:  Katharina Klatte; Timo Kirschstein; David Otte; Leonie Pothmann; Lorenz Müller; Tursonjan Tokay; Maria Kober; Mischa Uebachs; Andreas Zimmer; Heinz Beck
Journal:  J Neurosci       Date:  2013-08-07       Impact factor: 6.167

7.  Possible NMDA antagonist properties of drugs that affect high pressure neurological syndrome.

Authors:  M A Shuker; F Bowser-Riley; S N Davies
Journal:  Br J Pharmacol       Date:  1994-03       Impact factor: 8.739

8.  Effect of 1-aminocyclopropanecarboxylic acid on N-methyl-D-aspartate-stimulated [3H]-noradrenaline release in rat hippocampal synaptosomes.

Authors:  M V Clos; A Garcia Sanz; R Trullas; A Badia
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739

9.  Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate- and quisqualate-mediated depolarization of rat motoneurones in vitro.

Authors:  S K Long; D A Smith; R J Siarey; R H Evans
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

Review 10.  The NMDA receptor as a target for cognitive enhancement.

Authors:  Graham L Collingridge; Arturas Volianskis; Neil Bannister; Grace France; Lydia Hanna; Marion Mercier; Patrick Tidball; Guangyu Fang; Mark W Irvine; Blaise M Costa; Daniel T Monaghan; Zuner A Bortolotto; Elek Molnár; David Lodge; David E Jane
Journal:  Neuropharmacology       Date:  2012-07-11       Impact factor: 5.250
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