OBJECTIVE: Interpregnancy interval (IPI) influences numerous adverse perinatal outcomes. IPI's impact on birth defects is unclear. STUDY DESIGN: We conducted a population-based case-control study, using 1998 to 2008 administrative data from Washington State. A total of 10, 772 cases, women whose second of two births resulted in an infant with a birth defect, were compared with 32 ,310 controls, women whose second of two births did not result in an infant with a birth defect. RESULT: Compared with mothers with an IPI between 18 to 23 months, those with an IPI <6 months or ≥60 months had elevated risks of delivering an infant with a birth defect (odds ratio=1.15, 95% confidence interval: 1.03 to 1.28, and odds ratio=1.15, 95% confidence interval: 1.04 to 1.26, respectively). CONCLUSION: We observed a J-shaped relationship between IPI and risk of having an infant with a birth defect. As this is one of the first studies to evaluate this association, confirmatory studies are needed.
OBJECTIVE: Interpregnancy interval (IPI) influences numerous adverse perinatal outcomes. IPI's impact on birth defects is unclear. STUDY DESIGN: We conducted a population-based case-control study, using 1998 to 2008 administrative data from Washington State. A total of 10, 772 cases, women whose second of two births resulted in an infant with a birth defect, were compared with 32 ,310 controls, women whose second of two births did not result in an infant with a birth defect. RESULT: Compared with mothers with an IPI between 18 to 23 months, those with an IPI <6 months or ≥60 months had elevated risks of delivering an infant with a birth defect (odds ratio=1.15, 95% confidence interval: 1.03 to 1.28, and odds ratio=1.15, 95% confidence interval: 1.04 to 1.26, respectively). CONCLUSION: We observed a J-shaped relationship between IPI and risk of having an infant with a birth defect. As this is one of the first studies to evaluate this association, confirmatory studies are needed.
Authors: Esa M Davis; Denise C Babineau; Xuelei Wang; Stephen Zyzanski; Barbara Abrams; Lisa M Bodnar; Ralph I Horwitz Journal: Matern Child Health J Date: 2014-04
Authors: Julie M Petersen; Mahsa M Yazdy; Kelly D Getz; Marlene T Anderka; Martha M Werler Journal: Am J Clin Nutr Date: 2021-06-01 Impact factor: 7.045
Authors: Gizachew A Tessema; M Luke Marinovich; Siri E Håberg; Mika Gissler; Jonathan A Mayo; Natasha Nassar; Stephen Ball; Ana Pilar Betrán; Amanuel T Gebremedhin; Nick de Klerk; Maria C Magnus; Cicely Marston; Annette K Regan; Gary M Shaw; Amy M Padula; Gavin Pereira Journal: PLoS One Date: 2021-07-19 Impact factor: 3.240