OBJECTIVE: To study postnatal dexamethasone treatment effects on cognitive, neuropsychological and behavioral functioning at early school age in preterm children. STUDY DESIGN: We recruited 222 children born between 1998 and 2003: 114 extremely low birth weight (<1000 g; 60 dexamethasone-treated; 54 untreated) and 108 term-born. Data were analyzed using multivariate methods. RESULT: Preterm performed below term-born on all measures. Dexamethasone-treated performed below dexamethasone-untreated in immediate visual memory, visual-motor integration, mathematical skill and motor dexterity. However, stepwise regression indicated that medical and sociodemographic factors other than dexamethasone contributed to preterm group differences. CONCLUSION: Dexamethasone alone does not explain neurocognitive impairment in preterm children. Medical and sociodemographic factors (illness severity, male gender and parental education) are influential. Prospective longitudinal neuropsychological and behavioral study from preschool to school age that considers medical and sociodemographic variables will best address effects of dexamethasone exposure.
OBJECTIVE: To study postnatal dexamethasone treatment effects on cognitive, neuropsychological and behavioral functioning at early school age in preterm children. STUDY DESIGN: We recruited 222 children born between 1998 and 2003: 114 extremely low birth weight (<1000 g; 60 dexamethasone-treated; 54 untreated) and 108 term-born. Data were analyzed using multivariate methods. RESULT: Preterm performed below term-born on all measures. Dexamethasone-treated performed below dexamethasone-untreated in immediate visual memory, visual-motor integration, mathematical skill and motor dexterity. However, stepwise regression indicated that medical and sociodemographic factors other than dexamethasone contributed to preterm group differences. CONCLUSION:Dexamethasone alone does not explain neurocognitive impairment in preterm children. Medical and sociodemographic factors (illness severity, male gender and parental education) are influential. Prospective longitudinal neuropsychological and behavioral study from preschool to school age that considers medical and sociodemographic variables will best address effects of dexamethasone exposure.
Authors: Muhammad T K Zia; Govindaiah Vinukonda; Linnea R Vose; Bala B R Bhimavarapu; Sanda Iacobas; Nishi K Pandey; Ann Marie Beall; Preeti Dohare; Edmund F LaGamma; Dumitru A Iacobas; Praveen Ballabh Journal: Exp Neurol Date: 2014-09-28 Impact factor: 5.330
Authors: Noura Zayat; Patrick Truffert; Elodie Drumez; Alain Duhamel; Julien Labreuche; Michael Zemlin; David Milligan; Rolf F Maier; Pierre-Henri Jarreau; Héloïse Torchin; Jennifer Zeitlin; Alexandra Nuytten Journal: Int J Environ Res Public Health Date: 2022-05-05 Impact factor: 4.614
Authors: Carolien A van Houdt; Jaap Oosterlaan; Aleid G van Wassenaer-Leemhuis; Anton H van Kaam; Cornelieke S H Aarnoudse-Moens Journal: Dev Med Child Neurol Date: 2019-04-03 Impact factor: 5.449