Literature DB >> 21546695

HOX genes in pancreatic development and cancer.

Sophie Gray, Hardev S Pandha, Agnieszka Michael, Gary Middleton, Richard Morgan.   

Abstract

The HOX genes are a family of homeodomain-containing transcription factors that determine cellular identity during development and which are subsequently re-expressed in many types of cancer. Some recent studies have shown that HOX genes may have key roles both in pancreatic development and in adult diseases of the pancreas, including cancer. In this review we consider recent advances in elucidating the role of HOX genes in these processes, how they may connect early developmental events to subsequent adult disease, and their potential both as diagnostic markers and therapeutic targets.

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Year:  2011        PMID： 21546695

Source DB:  PubMed          Journal:  JOP        ISSN： 1590-8577


  17 in total

1.  Analysis of the Hox epigenetic code.

Authors:  Zoheir Ezziane
Journal:  World J Clin Oncol       Date:  2012-04-10

2.  HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma.

Authors:  Anne Nguyen Kovochich; Michael Arensman; Anna R Lay; Nagesh P Rao; Timothy Donahue; Xinmin Li; Samuel W French; David W Dawson
Journal:  Cancer       Date:  2012-08-22       Impact factor: 6.860

3.  Overexpression of homeobox B-13 correlates with angiogenesis, aberrant expression of EMT markers, aggressive characteristics and poor prognosis in pancreatic carcinoma.

Authors:  Lu-Lu Zhai; Yang Wu; Chong-Yang Cai; Zhi-Gang Tang
Journal:  Int J Clin Exp Pathol       Date:  2015-06-01

4.  Upregulation of lncRNA147410.3 in the Brain of Mice With Chronic Toxoplasma Infection Promoted Microglia Apoptosis by Regulating Hoxb3.

Authors:  Yongliang Wang; Ruxia Han; Zhejun Xu; Xiahui Sun; Chunxue Zhou; Bing Han; Shenyi He; Hua Cong
Journal:  Front Cell Neurosci       Date:  2021-05-18       Impact factor: 5.505

5.  Detection of IGF2BP3, HOXB7, and NEK2 mRNA expression in brush cytology specimens as a new diagnostic tool in patients with biliary strictures.

Authors:  Hans Dieter Nischalke; Volker Schmitz; Carolin Luda; Katharina Aldenhoff; Cordula Berger; Georg Feldmann; Tilman Sauerbruch; Ulrich Spengler; Jacob Nattermann
Journal:  PLoS One       Date:  2012-08-07       Impact factor: 3.240

6.  MiRNA-615-5p functions as a tumor suppressor in pancreatic ductal adenocarcinoma by targeting AKT2.

Authors:  Yang Sun; Tingting Zhang; Cuiping Wang; Xianglan Jin; Congwei Jia; Shuangni Yu; Jie Chen
Journal:  PLoS One       Date:  2015-04-09       Impact factor: 3.240

7.  The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration.

Authors:  Yating Cheng; Indira Jutooru; Gayathri Chadalapaka; J Christopher Corton; Stephen Safe
Journal:  Oncotarget       Date:  2015-05-10

8.  HOXB7 mRNA is overexpressed in pancreatic ductal adenocarcinomas and its knockdown induces cell cycle arrest and apoptosis.

Authors:  Thais Chile; Maria Angela Henriques Zanella Fortes; Maria Lúcia Cardillo Corrêa-Giannella; Helena Paula Brentani; Durvanei Augusto Maria; Renato David Puga; Vanessa de Jesus R de Paula; Marcia Saldanha Kubrusly; Estela Maria Novak; Telésforo Bacchella; Ricardo Rodrigues Giorgi
Journal:  BMC Cancer       Date:  2013-10-02       Impact factor: 4.430

9.  Levels of HOXB7 and miR-337 in pancreatic ductal adenocarcinoma patients.

Authors:  Rui Zhang; Shangen Zheng; Yuwen Du; Yuanyuan Wang; Wenqiao Zang; Guoqiang Zhao
Journal:  Diagn Pathol       Date:  2014-03-18       Impact factor: 2.644

10.  Systems biology approach to stage-wise characterization of epigenetic genes in lung adenocarcinoma.

Authors:  Meeta P Pradhan; Akshay Desai; Mathew J Palakal
Journal:  BMC Syst Biol       Date:  2013-12-26
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