| Literature DB >> 2154621 |
H Vennema1, R J de Groot, D A Harbour, M Dalderup, T Gruffydd-Jones, M C Horzinek, W J Spaan.
Abstract
The gene encoding the fusogenic spike protein of the coronavirus causing feline infectious peritonitis was recombined into the genome of vaccinia virus. The recombinant induced spike-protein-specific, in vitro neutralizing antibodies in mice. When kittens were immunized with the recombinant, low titers of neutralizing antibodies were obtained. After challenge with feline infectious peritonitis virus, these animals succumbed earlier than did the control group immunized with wild-type vaccinia virus (early death syndrome).Entities:
Mesh:
Substances:
Year: 1990 PMID: 2154621 PMCID: PMC249267 DOI: 10.1128/JVI.64.3.1407-1409.1990
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103