BACKGROUND: The aim of this study was to determine the relationship between airway blood flow (Q(aw)), airway conductance (G(f-aw)) and pulmonary function in patients with stable HF. METHODS: 12 controls (CTRL: age=63±9 years, FVC=98±15%pred, LVEF=61±6%) (all data presented as mean±SD), 16 patients with mild HF (HF-A, NYHA I-II: age=64±9 years, FVC=90±17%pred, LVEF=28±6%), and 14 patients with moderate/severe HF (HF-B, NYHA III-IV: age=65±6 years, FVC=84±12%pred, LVEF=26±6%) were studied. Q(aw) was assessed using soluble gas measurements; perfusion pressure across airway bed (ΔP(aw)) was estimated from systemic and pulmonary pressure measurements; G(f-aw) was calculated as Q(aw)/ΔP(aw); PF was assessed by spirometry. RESULTS: While Q˙(aw) was not significantly different between CTRL (61.3±17.9 μL min(-1)mL(-1)), HF-A (70.1±26.9 μL min(-1)mL(-1)) and HF-B (56.2±14.9 μL min(-1)mL(-1)) groups, G(f-aw), was elevated in HF-A (1.1±0.4 μL min(-1)mL(-1)mm Hg(-1), p<0.03) and tended to be elevated in HF-B (1.2±0.6 μL min(-1)mL(-1)mm Hg(-1), p=0.07) when compared to CTRL (0.8±0.3 μL min(-1)mL(-1)mm Hg(-1)). Significant positive correlations were found between G(f-aw) and RV/TLC for HF-A (r=0.63, p<0.02) and HF-B (r=0.58, p<0.05). CONCLUSIONS: These results support the hypothesis that increased bronchial conductance and bronchial congestion may be related to greater small airway obstruction and as such may play a role in the PF abnormalities and symptoms of congestion commonly observed in HF patients.
BACKGROUND: The aim of this study was to determine the relationship between airway blood flow (Q(aw)), airway conductance (G(f-aw)) and pulmonary function in patients with stable HF. METHODS: 12 controls (CTRL: age=63±9 years, FVC=98±15%pred, LVEF=61±6%) (all data presented as mean±SD), 16 patients with mild HF (HF-A, NYHA I-II: age=64±9 years, FVC=90±17%pred, LVEF=28±6%), and 14 patients with moderate/severe HF (HF-B, NYHA III-IV: age=65±6 years, FVC=84±12%pred, LVEF=26±6%) were studied. Q(aw) was assessed using soluble gas measurements; perfusion pressure across airway bed (ΔP(aw)) was estimated from systemic and pulmonary pressure measurements; G(f-aw) was calculated as Q(aw)/ΔP(aw); PF was assessed by spirometry. RESULTS: While Q˙(aw) was not significantly different between CTRL (61.3±17.9 μL min(-1)mL(-1)), HF-A (70.1±26.9 μL min(-1)mL(-1)) and HF-B (56.2±14.9 μL min(-1)mL(-1)) groups, G(f-aw), was elevated in HF-A (1.1±0.4 μL min(-1)mL(-1)mm Hg(-1), p<0.03) and tended to be elevated in HF-B (1.2±0.6 μL min(-1)mL(-1)mm Hg(-1), p=0.07) when compared to CTRL (0.8±0.3 μL min(-1)mL(-1)mm Hg(-1)). Significant positive correlations were found between G(f-aw) and RV/TLC for HF-A (r=0.63, p<0.02) and HF-B (r=0.58, p<0.05). CONCLUSIONS: These results support the hypothesis that increased bronchial conductance and bronchial congestion may be related to greater small airway obstruction and as such may play a role in the PF abnormalities and symptoms of congestion commonly observed in HF patients.
Authors: L R Cabanes; S N Weber; R Matran; J Regnard; M O Richard; M E Degeorges; A Lockhart Journal: N Engl J Med Date: 1989-05-18 Impact factor: 91.245
Authors: Norman R Morris; Maile L Ceridon; Kenneth C Beck; Nicholas A Strom; Donald A Schneider; Eliana S Mendes; Adam Wanner; Bruce D Johnson Journal: Respir Physiol Neurobiol Date: 2008-07-05 Impact factor: 1.931
Authors: Troy J Cross; Surendan Sabapathy; Kenneth C Beck; Norman R Morris; Bruce D Johnson Journal: Eur Respir J Date: 2011-10-27 Impact factor: 16.671
Authors: Maile L Ceridon; Norman R Morris; Thomas P Olson; Sophie Lalande; Bruce D Johnson Journal: Respir Physiol Neurobiol Date: 2011-06-30 Impact factor: 1.931
Authors: Ivan Cundrle; Bruce D Johnson; Virend K Somers; Christopher G Scott; Robert F Rea; Lyle J Olson Journal: Am J Cardiol Date: 2013-06-05 Impact factor: 2.778
Authors: Sophie Lalande; Troy J Cross; Manda L Keller-Ross; Norman R Morris; Bruce D Johnson; Bryan J Taylor Journal: Exerc Sport Sci Rev Date: 2020-01 Impact factor: 6.642
Authors: Pavol Sajgalik; Chul-Ho Kim; John M Stulak; Sudhir S Kushwaha; Simon Maltais; David L Joyce; Lyle D Joyce; Bruce D Johnson; John A Schirger Journal: ESC Heart Fail Date: 2018-10-12