| Literature DB >> 21545828 |
Dalibor Cerný1, Nataša Lekić, Kateřina Váňová, Lucie Muchová, Aleš Hořínek, Eva Kmoníčková, Zdeněk Zídek, Ludmila Kameníková, Hassan Farghali.
Abstract
This work studied a relationship between HO-1/CO system and lipid peroxidation with consequent effects on liver functions and NOS-2. We focused on curcumin pretreatment in rat toxic model of d-galactosamine and lipopolysaccharide. Hepatocyte viability, lipid peroxidation, antioxidant status, ALT and AST were evaluated. HO-1 and NOS-2 expressions and respective enzyme activity were determined. Curcumin caused decreases in ALT and AST levels as well as in lipid peroxidation. Furthermore, curcumin pretreatment increased liver HO-1 (2.4-fold, p=0.001), but reduced NOS-2 (4.1-fold, p=0.01) expressions. In conclusion, the tuning of CO/NO pathways is important in shedding light on curcumin's cytoprotective effects in this model.Entities:
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Year: 2011 PMID： 21545828 DOI： 10.1016/j.fitote.2011.04.003
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882