Literature DB >> 21544566

Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson's disease.

Alex Tsui1, Ole Isacson.   

Abstract

While pharmaceutical options remain the overwhelmingly accepted treatment of choice for neurological and psychiatric diseases, significant accomplishments in regenerative neuroscience research have demonstrated the potential of cellular and synaptic functional repair in future therapies. Parkinson's disease stands out as an example in which repair by dopaminergic neurons appears a viable potential therapy. This article describes the basic neurobiological underpinnings of the rationale for cell therapy for Parkinson's disease and the challenges ahead for the use of regenerative medicine in the treatment for this disease.

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Year:  2011        PMID： 21544566     DOI： 10.1007/s00415-011-6061-6

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  75 in total

1.  Regulation of phosphorylation of the GluR1 AMPA receptor in the neostriatum by dopamine and psychostimulants in vivo.

Authors:  G L Snyder; P B Allen; A A Fienberg; C G Valle; R L Huganir; A C Nairn; P Greengard
Journal:  J Neurosci       Date:  2000-06-15       Impact factor: 6.167

2.  Mu- and delta-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.

Authors:  B Henry; S H Fox; A R Crossman; J M Brotchie
Journal:  Exp Neurol       Date:  2001-09       Impact factor: 5.330

3.  3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists.

Authors:  A CARLSSON; M LINDQVIST; T MAGNUSSON
Journal:  Nature       Date:  1957-11-30       Impact factor: 49.962

4.  Assessing fetal nerve cell grafts in Parkinson's disease.

Authors:  Heiko Braak; Kelly Del Tredici
Journal:  Nat Med       Date:  2008-05       Impact factor: 53.440

5.  Brain stem pathology in Parkinson's disease: an evaluation of the Braak staging model.

Authors:  Ann E Kingsbury; Rina Bandopadhyay; Laura Silveira-Moriyama; Hilary Ayling; Constantinos Kallis; William Sterlacci; Hans Maeir; Werner Poewe; Andrew J Lees
Journal:  Mov Disord       Date:  2010-11-15       Impact factor: 10.338

6.  The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease.

Authors:  Shane Grealish; Marie E Jönsson; Meng Li; Deniz Kirik; Anders Björklund; Lachlan H Thompson
Journal:  Brain       Date:  2010-01-31       Impact factor: 13.501

Review 7.  DARPP-32 and modulation of cAMP signaling: involvement in motor control and levodopa-induced dyskinesia.

Authors:  Kerstin Håkansson; Maria Lindskog; Laura Pozzi; Alessandro Usiello; Gilberto Fisone
Journal:  Parkinsonism Relat Disord       Date:  2004-07       Impact factor: 4.891

8.  Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms.

Authors:  Kuei Y Tseng; Patricio O'Donnell
Journal:  J Neurosci       Date:  2004-06-02       Impact factor: 6.167

Review 9.  Cholinergic and other neurotransmitter mechanisms in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies.

Authors:  Paul T Francis; Elaine K Perry
Journal:  Mov Disord       Date:  2007-09       Impact factor: 10.338

10.  Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease.

Authors:  A Vinuela; P J Hallett; C Reske-Nielsen; M Patterson; T D Sotnikova; M G Caron; R R Gainetdinov; O Isacson
Journal:  Brain       Date:  2008-11-06       Impact factor: 13.501
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  17 in total

1.  Study of a fetal brain affected by a severe form of tyrosine hydroxylase deficiency, a rare cause of early parkinsonism.

Authors:  Alba Tristán-Noguero; Héctor Díez; Cristina Jou; Mercè Pineda; Aida Ormazábal; Aurora Sánchez; Rafael Artuch; Àngels Garcia-Cazorla
Journal:  Metab Brain Dis       Date:  2015-12-21       Impact factor: 3.584

2.  Sorting the wheat from the chaff in dopamine neuron-based cell therapies.

Authors:  Ole Isacson
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-06       Impact factor: 11.205

3.  Nanodelivery of Cerebrolysin and Rearing in Enriched Environment Induce Neuroprotective Effects in a Preclinical Rat Model of Parkinson's Disease.

Authors:  C Requejo; J A Ruiz-Ortega; H Cepeda; A Sharma; H S Sharma; A Ozkizilcik; R Tian; H Moessler; L Ugedo; J V Lafuente
Journal:  Mol Neurobiol       Date:  2018-01       Impact factor: 5.590

Review 4.  Treating non-motor symptoms of Parkinson's disease with transplantation of stem cells.

Authors:  Paolina Pantcheva; Stephanny Reyes; Jaclyn Hoover; Sussannah Kaelber; Cesar V Borlongan
Journal:  Expert Rev Neurother       Date:  2015-09-22       Impact factor: 4.618

5.  Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's disease.

Authors:  Yu Zhang; I-Wei Wu; Shannon Buckley; Christopher S Coffey; Eric Foster; Susan Mendick; John Seibyl; Norbert Schuff
Journal:  Mov Disord       Date:  2015-04-29       Impact factor: 10.338

6.  Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease.

Authors:  Penelope J Hallett; Michela Deleidi; Arnar Astradsson; Gaynor A Smith; Oliver Cooper; Teresia M Osborn; Maria Sundberg; Michele A Moore; Eduardo Perez-Torres; Anna-Liisa Brownell; James M Schumacher; Roger D Spealman; Ole Isacson
Journal:  Cell Stem Cell       Date:  2015-02-26       Impact factor: 24.633

7.  Dopamine receptors in human embryonic stem cell neurodifferentiation.

Authors:  Glenn S Belinsky; Carissa L Sirois; Matthew T Rich; Shaina M Short; Anna R Moore; Sarah E Gilbert; Srdjan D Antic
Journal:  Stem Cells Dev       Date:  2013-02-19       Impact factor: 3.272

8.  Clinical translation of stem cells in neurodegenerative disorders.

Authors:  Olle Lindvall; Roger A Barker; Oliver Brüstle; Ole Isacson; Clive N Svendsen
Journal:  Cell Stem Cell       Date:  2012-02-03       Impact factor: 24.633

9.  Proteomic Profiling of the Substantia Nigra to Identify Determinants of Lewy Body Pathology and Dopaminergic Neuronal Loss.

Authors:  Vladislav A Petyuk; Lei Yu; Heather M Olson; Fengchao Yu; Geremy Clair; Wei-Jun Qian; Joshua M Shulman; David A Bennett
Journal:  J Proteome Res       Date:  2021-04-26       Impact factor: 5.370

10.  PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice.

Authors:  YaJun Zhang; Ann-Charlotte Granholm; Kyounghee Huh; Lufei Shan; Oscar Diaz-Ruiz; Nasir Malik; Lars Olson; Barry J Hoffer; Carl R Lupica; Alexander F Hoffman; Cristina M Bäckman
Journal:  Brain       Date:  2012-09       Impact factor: 13.501
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