Sebastian Köhler1, Martin van Boxtel, Jelle Jolles, Frans Verhey. 1. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Amsterdam, the Netherlands. s.koehler@maastrichtuniversity.nl
Abstract
OBJECTIVE: Depression relates to vascular disease and is a candidate risk factor for dementia. We assessed the risk associated with depressive symptoms for Alzheimer-type dementia and vascular dementia. METHODS: Depressive symptoms (SCL-90 depression subscale) were assessed in 771 community-dwelling individuals age 55 years and older. Onset of dementia (N = 37) was recorded at serial assessments 3, 6, and 9 years after baseline. RESULTS: Depressive symptom scores predicted all-type dementia (OR = 1.06, 95% CI = 1.01-1.10), and vascular dementia (OR = 1.11; 95% CI = 1.03-1.19), but not Alzheimer-type dementia (OR = 1.04; 95% CI = 0.98-1.09). People scoring in the upper quartile of the SCL-90 depression scale (N = 180) were at increased risk for dementia (OR = 2.06, 95% CI = 1.01-4.22). Results were unchanged after co-varying for baseline mini-mental state exam and presence of vascular disease. CONCLUSION: Depressive symptoms increase the risk for later dementia in community-dwelling older adults.
OBJECTIVE:Depression relates to vascular disease and is a candidate risk factor for dementia. We assessed the risk associated with depressive symptoms for Alzheimer-type dementia and vascular dementia. METHODS:Depressive symptoms (SCL-90 depression subscale) were assessed in 771 community-dwelling individuals age 55 years and older. Onset of dementia (N = 37) was recorded at serial assessments 3, 6, and 9 years after baseline. RESULTS:Depressive symptom scores predicted all-type dementia (OR = 1.06, 95% CI = 1.01-1.10), and vascular dementia (OR = 1.11; 95% CI = 1.03-1.19), but not Alzheimer-type dementia (OR = 1.04; 95% CI = 0.98-1.09). People scoring in the upper quartile of the SCL-90 depression scale (N = 180) were at increased risk for dementia (OR = 2.06, 95% CI = 1.01-4.22). Results were unchanged after co-varying for baseline mini-mental state exam and presence of vascular disease. CONCLUSION:Depressive symptoms increase the risk for later dementia in community-dwelling older adults.
Authors: Breno S Diniz; Meryl A Butters; Steven M Albert; Mary Amanda Dew; Charles F Reynolds Journal: Br J Psychiatry Date: 2013-05 Impact factor: 9.319
Authors: Ryan K McBain; Carmel Salhi; Katrina Hann; Joshua A Salomon; Jane J Kim; Theresa S Betancourt Journal: Health Policy Plan Date: 2015-09-07 Impact factor: 3.344