Literature DB >> 21543720

The inflammasome in atherosclerosis and type 2 diabetes.

Seth L Masters1, Eicke Latz, Luke A J O'Neill.   

Abstract

Atherosclerosis is the cause of morbiditiy for 70% of patients with type 2 diabetes. In both of these diseases, a protein complex known as the inflammasome is stimulated to activate interleukin-1β (IL-1β) and IL-18, which are pathogenic inflammatory cytokines. Triggers for the inflammasome are obesity-related factors, such as cholesterol crystals in atherosclerosis, or hyperglycemia, ceramides, and islet amyloid polypeptide in type 2 diabetes. Therapeutics that target IL-1β in clinical trials for type 2 diabetes might also decrease the incidence of atherosclerosis.

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Year:  2011        PMID： 21543720     DOI： 10.1126/scitranslmed.3001902

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  65 in total

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Review 3.  Macrophage polarization and plasticity in health and disease.

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4.  Chlamydia and Lipids Engage a Common Signaling Pathway That Promotes Atherogenesis.

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5.  Association of subclinical inflammation with deterioration of glycaemia before the diagnosis of type 2 diabetes: the KORA S4/F4 study.

Authors:  Birgit Klüppelholz; Barbara Thorand; Wolfgang Koenig; Tonia de Las Heras Gala; Christa Meisinger; Cornelia Huth; Guido Giani; Paul W Franks; Michael Roden; Wolfgang Rathmann; Annette Peters; Christian Herder
Journal:  Diabetologia       Date:  2015-07-09       Impact factor: 10.122

Review 6.  Target acquired: Selective autophagy in cardiometabolic disease.

Authors:  Trent D Evans; Ismail Sergin; Xiangyu Zhang; Babak Razani
Journal:  Sci Signal       Date:  2017-02-28       Impact factor: 8.192

7.  Autophagy links inflammasomes to atherosclerotic progression.

Authors:  Babak Razani; Chu Feng; Trey Coleman; Roy Emanuel; Haitao Wen; Seungmin Hwang; Jenny P Ting; Herbert W Virgin; Michael B Kastan; Clay F Semenkovich
Journal:  Cell Metab       Date:  2012-03-20       Impact factor: 27.287

8.  Alterations of Cholesterol Metabolism in Inflammation-Induced Atherogenesis.

Authors:  David P Hajjar; Katherine A Hajjar
Journal:  J Enzymol Metab       Date:  2016-05-31

9.  Cyclooxygenase 2, toll-like receptor 4 and interleukin 1β mRNA expression in atherosclerotic plaques of type 2 diabetic patients.

Authors:  Alessandro Baldan; Silvia Ferronato; Silvia Olivato; Giovanni Malerba; Alberto Scuro; Gian Franco Veraldi; Matteo Gelati; Sergio Ferrari; Sara Mariotto; Pier Franco Pignatti; Sara Mazzucco; Macarena Gomez-Lira
Journal:  Inflamm Res       Date:  2014-08-06       Impact factor: 4.575

Review 10.  Innate immune activation in obesity.

Authors:  Carey N Lumeng
Journal:  Mol Aspects Med       Date:  2012-10-13
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