Literature DB >> 21543717

A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD mice.

Anna Morena D'Alise1, Ayla Ergun, Jonathan A Hill, Diane Mathis, Christophe Benoist.   

Abstract

Foxp3(+) regulatory T cells (Tregs) originate in the thymus, but the Treg phenotype can also be induced in peripheral lymphoid organs or in vitro by stimulation of conventional CD4(+) T cells with IL-2 and TGF-β. There have been divergent reports on the suppressive capacity of these TGF-Treg cells. We find that TGF-Tregs derived from diabetes-prone NOD mice, although expressing normal Foxp3 levels, are uniquely defective in suppressive activity, whereas TGF-Tregs from control strains (B6g7) or ex vivo Tregs from NOD mice all function normally. Most Treg-typical transcripts were shared by NOD or B6g7 TGF-Tregs, except for a small group of differentially expressed genes, including genes relevant for suppressive activity (Lrrc32, Ctla4, and Cd73). Many of these transcripts form a coregulated cluster in a broader analysis of T-cell differentiation. The defect does not map to idd3 or idd5 regions. Whereas Treg cells from NOD mice are normal in spleen and lymph nodes, the NOD defect is observed in locations that have been tied to pathogenesis of diabetes (small intestine lamina propria and pancreatic lymph node). Thus, a genetic defect uniquely affects a specific Treg subpopulation in NOD mice, in a manner consistent with a role in determining diabetes susceptibility.

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Year:  2011        PMID: 21543717      PMCID: PMC3102351          DOI: 10.1073/pnas.1105364108

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  49 in total

1.  The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors.

Authors:  Anna Morena D'Alise; Vincent Auyeung; Markus Feuerer; Junko Nishio; Jason Fontenot; Christophe Benoist; Diane Mathis
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-10       Impact factor: 11.205

2.  The Immunological Genome Project: networks of gene expression in immune cells.

Authors:  Tracy S P Heng; Michio W Painter
Journal:  Nat Immunol       Date:  2008-10       Impact factor: 25.606

3.  Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells.

Authors:  Rui Wang; Lina Kozhaya; Frances Mercer; Alka Khaitan; Hodaka Fujii; Derya Unutmaz
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-28       Impact factor: 11.205

4.  The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells.

Authors:  Anya Schneider; Mary Rieck; Srinath Sanda; Catherine Pihoker; Carla Greenbaum; Jane H Buckner
Journal:  J Immunol       Date:  2008-11-15       Impact factor: 5.422

5.  Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg.

Authors:  Julie Stockis; Didier Colau; Pierre G Coulie; Sophie Lucas
Journal:  Eur J Immunol       Date:  2009-12       Impact factor: 5.532

6.  GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.

Authors:  Dat Q Tran; John Andersson; Rui Wang; Heather Ramsey; Derya Unutmaz; Ethan M Shevach
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-27       Impact factor: 11.205

7.  CTLA-4 control over Foxp3+ regulatory T cell function.

Authors:  Kajsa Wing; Yasushi Onishi; Paz Prieto-Martin; Tomoyuki Yamaguchi; Makoto Miyara; Zoltan Fehervari; Takashi Nomura; Shimon Sakaguchi
Journal:  Science       Date:  2008-10-10       Impact factor: 47.728

8.  TGF-beta-induced Foxp3+ regulatory T cells rescue scurfy mice.

Authors:  Eva N Huter; George A Punkosdy; Deborah D Glass; Lily I Cheng; Jerrold M Ward; Ethan M Shevach
Journal:  Eur J Immunol       Date:  2008-07       Impact factor: 5.532

9.  Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.

Authors:  Qizhi Tang; Jason Y Adams; Cristina Penaranda; Kristin Melli; Eliane Piaggio; Evridiki Sgouroudis; Ciriaco A Piccirillo; Benoit L Salomon; Jeffrey A Bluestone
Journal:  Immunity       Date:  2008-05-08       Impact factor: 31.745

Review 10.  The "perfect storm" for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity.

Authors:  Outi Vaarala; Mark A Atkinson; Josef Neu
Journal:  Diabetes       Date:  2008-10       Impact factor: 9.461

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  21 in total

Review 1.  Treg cells, life history, and diversity.

Authors:  Christophe Benoist; Diane Mathis
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-09-01       Impact factor: 10.005

2.  Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance.

Authors:  Siyoung Yang; Noriyuki Fujikado; Dmitriy Kolodin; Christophe Benoist; Diane Mathis
Journal:  Science       Date:  2015-03-19       Impact factor: 47.728

3.  Gut immune deficits in LEW.1AR1-iddm rats partially overcome by feeding a diabetes-protective diet.

Authors:  Jennifer A Crookshank; Christopher Patrick; Gen-Sheng Wang; J Ariana Noel; Fraser W Scott
Journal:  Immunology       Date:  2015-03-29       Impact factor: 7.397

4.  Myeloid-derived suppressor cells protect islet transplants by B7-H1 mediated enhancement of T regulatory cells.

Authors:  Hong-Shiue Chou; Ching-Chuan Hsieh; Ronald Charles; Lianfu Wang; Timothy Wagner; John J Fung; Shiguang Qian; Lina L Lu
Journal:  Transplantation       Date:  2012-02-15       Impact factor: 4.939

5.  Innate and adaptive immune gene expression profiles as biomarkers in human type 1 diabetes.

Authors:  D Han; X Cai; J Wen; D Matheson; J S Skyler; N S Kenyon; Z Chen
Journal:  Clin Exp Immunol       Date:  2012-11       Impact factor: 4.330

6.  Altered connexin 43 expression underlies age-dependent decrease of regulatory T cell suppressor function in nonobese diabetic mice.

Authors:  Michal Kuczma; Cong-Yi Wang; Leszek Ignatowicz; Robert Gourdie; Piotr Kraj
Journal:  J Immunol       Date:  2015-04-24       Impact factor: 5.422

7.  CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice.

Authors:  Cheng Ye; Benjamin E Low; Michael V Wiles; Todd M Brusko; David V Serreze; John P Driver
Journal:  J Immunol       Date:  2020-08-31       Impact factor: 5.422

Review 8.  Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment.

Authors:  Chie Hotta-Iwamura; Kristin V Tarbell
Journal:  J Leukoc Biol       Date:  2016-01-20       Impact factor: 4.962

9.  GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.

Authors:  Angela X Zhou; Lina Kozhaya; Hodaka Fujii; Derya Unutmaz
Journal:  J Immunol       Date:  2013-04-10       Impact factor: 5.422

Review 10.  CD73 and adenosine generation in the creation of regulatory microenvironments.

Authors:  F S Regateiro; S P Cobbold; H Waldmann
Journal:  Clin Exp Immunol       Date:  2013-01       Impact factor: 4.330

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