| Literature DB >> 21543226 |
Savithri Ramurthy1, Mina Aikawa, Payman Amiri, Abran Costales, Ahmad Hashash, Johanna M Jansen, Song Lin, Sylvia Ma, Paul A Renhowe, Cynthia M Shafer, Sharadha Subramanian, Leonard Sung, Joelle Verhagen.
Abstract
Two scaffolds based on 5,6-fused heterocyclic backbones were designed and synthesized as Raf kinase inhibitors. The scaffolds were assessed for in vitro pan-Raf inhibition, activity in cell proliferation and target modulation assays, and pharmacokinetic parameters.Entities:
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Year: 2011 PMID： 21543226 DOI： 10.1016/j.bmcl.2011.04.023
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823