Literature DB >> 21543121

Recombination mapping of the susceptibility region for sporadic inclusion body myositis within the major histocompatibility complex.

Adrian P Scott1, Nigel G Laing, Frank Mastaglia, Merrilee Needham, Maggie C Walter, Marinos C Dalakas, Richard J N Allcock.   

Abstract

Susceptibility to sporadic inclusion body myositis (sIBM) in Caucasians has been consistently associated with alleles of the major histocompatibility complex (MHC) 8.1 ancestral haplotype (AH) (defined by HLA-B*0801 and HLA-DRB1*0301). In this study recombination mapping was utilised to further refine the known 8.1AH susceptibility region near HLA-DRB1*0301. Caucasian sIBM patients carrying part of the 8.1AH were genotyped for a selection of 8.1AH-haplotypic polymorphisms. A common 8.1AH-specific susceptibility region was defined, spanning 172 kb and encompassing three genes--HLA-DRB3, HLA-DRA and BTNL2. It is thus likely that 8.1AH-derived susceptibility to sIBM originates from at least one of these genes.
Copyright © 2011. Published by Elsevier B.V.

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Year:  2011        PMID： 21543121     DOI： 10.1016/j.jneuroim.2011.02.011

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  7 in total

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Authors:  Johanna Aigner; Sergi Villatoro; Raquel Rabionet; Jaume Roquer; Jordi Jiménez-Conde; Eulàlia Martí; Xavier Estivill
Journal:  BMC Genet       Date:  2013-07-06       Impact factor: 2.797

3.  Identification of Hub Genes and Biological Pathways in Inclusion Body Myositis Using Bioinformatics Analysis.

Authors:  Yue Wu; Zijun Zhao; Jinru Zhang; Yaye Wang; Xueqin Song
Journal:  Int J Gen Med       Date:  2022-02-09

4.  Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.

Authors:  F W Miller; W Chen; T P O'Hanlon; R G Cooper; J Vencovsky; L G Rider; K Danko; L R Wedderburn; I E Lundberg; L M Pachman; A M Reed; S R Ytterberg; L Padyukov; A Selva-O'Callaghan; T R Radstake; D A Isenberg; H Chinoy; W E R Ollier; P Scheet; B Peng; A Lee; J Byun; J A Lamb; P K Gregersen; C I Amos
Journal:  Genes Immun       Date:  2015-08-20       Impact factor: 2.676

Review 5.  Emerging therapeutic options for sporadic inclusion body myositis.

Authors:  Lindsay N Alfano; Linda P Lowes
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Review 6.  Ongoing developments in sporadic inclusion body myositis.

Authors:  Pedro M Machado; Mhoriam Ahmed; Stefen Brady; Qiang Gang; Estelle Healy; Jasper M Morrow; Amanda C Wallace; Liz Dewar; Gita Ramdharry; Matthew Parton; Janice L Holton; Henry Houlden; Linda Greensmith; Michael G Hanna
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Review 7.  Sporadic inclusion body myositis: the genetic contributions to the pathogenesis.

Authors:  Qiang Gang; Conceição Bettencourt; Pedro Machado; Michael G Hanna; Henry Houlden
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  7 in total

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