| Literature DB >> 21542633 |
Huaizhi Kang1, Anna Carolina Trondoli, Guizhi Zhu, Yan Chen, Ya-Jen Chang, Haipeng Liu, Yu-Fen Huang, Xiaoling Zhang, Weihong Tan.
Abstract
A near-infrared light-responsive drug delivery platform based on Au-Ag nanorods (Au-Ag NRs) coated with DNA cross-linked polymeric shells was constructed. DNA complementarity has been applied to develop a polyacrylamide-based sol-gel transition system to encapsulate anticancer drugs into the gel scaffold. The Au-Ag NR-based nanogels can also be readily functionalized with targeting moieties, such as aptamers, for specific recognition of tumor cells. When exposed to NIR irradiation, the photothermal effect of the Au-Ag NRs leads to a rapid rise in the temperature of the surrounding gel, resulting in the fast release of the encapsulated payload with high controllability. In vitro study confirmed that aptamer-functionalized nanogels can be used as drug carriers for targeted drug delivery with remote control capability by NIR light with high spatial/temporal resolution.Entities:
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Year: 2011 PMID： 21542633 PMCID： PMC3125410 DOI： 10.1021/nn201171r
Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881