OBJECTIVES: To determine the incidence of depression in head and neck cancer (HNCA) patients and the effect of depression on baseline head- and neck-specific measures of quality of life and function. STUDY DESIGN: Prospective cohort analysis. METHODS: A total of 255 patients were prospectively evaluated using the Beck Depression Inventory Fast-Screen (BDI-FS) survey, University of Washington Quality of Life (UW QOL), Voice Handicap Index (VHI), and MD Anderson Dysphagia Inventory (MDADI) questionnaires. Patients with a preexisting diagnosis of depression were excluded. RESULTS: Complete data were available for 77 patients with HNCA and 53 controls. Depressive symptoms were identified in 9% of controls and 19% of HNCA patients, and were significantly associated with a HNCA diagnosis (OR = 4.1, P = .044). Among patients with HNCA, depression was significantly more common in black patients (OR = 15.8, P = .017). A significant negative correlation was found between BDI-FS score and UW global QOL score (r = -0.4, P = .0019). Depression was significantly associated with poorer UW global QOL (β = -22.46, P = .0004), recreation (β = -13.77, P = .037), speech (β = -24.05, P = .004), and MDADI functional (β = -17.31, P = .009), physical (β = -14.99, P = .032), and emotional (β = -11.60, P = .049) domain scores but not with other UW QOL or VHI domains, after controlling for all other variables. CONCLUSIONS: Patients with HNCA have a high incidence of depressive symptoms at diagnosis, which is significantly higher in black patients, and is associated with poorer QOL and MDADI scores. Pretreatment depression may serve as a marker for patients with increased risk of swallowing impairment and reduced QOL who would benefit from targeted intervention.
OBJECTIVES: To determine the incidence of depression in head and neck cancer (HNCA) patients and the effect of depression on baseline head- and neck-specific measures of quality of life and function. STUDY DESIGN: Prospective cohort analysis. METHODS: A total of 255 patients were prospectively evaluated using the Beck Depression Inventory Fast-Screen (BDI-FS) survey, University of Washington Quality of Life (UW QOL), Voice Handicap Index (VHI), and MD Anderson Dysphagia Inventory (MDADI) questionnaires. Patients with a preexisting diagnosis of depression were excluded. RESULTS: Complete data were available for 77 patients with HNCA and 53 controls. Depressive symptoms were identified in 9% of controls and 19% of HNCA patients, and were significantly associated with a HNCA diagnosis (OR = 4.1, P = .044). Among patients with HNCA, depression was significantly more common in black patients (OR = 15.8, P = .017). A significant negative correlation was found between BDI-FS score and UW global QOL score (r = -0.4, P = .0019). Depression was significantly associated with poorer UW global QOL (β = -22.46, P = .0004), recreation (β = -13.77, P = .037), speech (β = -24.05, P = .004), and MDADI functional (β = -17.31, P = .009), physical (β = -14.99, P = .032), and emotional (β = -11.60, P = .049) domain scores but not with other UW QOL or VHI domains, after controlling for all other variables. CONCLUSIONS:Patients with HNCA have a high incidence of depressive symptoms at diagnosis, which is significantly higher in black patients, and is associated with poorer QOL and MDADI scores. Pretreatment depression may serve as a marker for patients with increased risk of swallowing impairment and reduced QOL who would benefit from targeted intervention.
Authors: Namie Okino Sawada; Juliana Maria de Paula; Helena Megumi Sonobe; Marcia Maria Fontão Zago; Giselle Patricia Guerrero; Adriana Cristina Nicolussi Journal: Support Care Cancer Date: 2012-11 Impact factor: 3.603
Authors: Carolyn Y Fang; Brian L Egleston; John A Ridge; Miriam N Lango; Dana H Bovbjerg; Jamie L Studts; Barbara A Burtness; Margret B Einarson; Andres J P Klein-Szanto Journal: Head Neck Date: 2013-10-26 Impact factor: 3.147
Authors: Timothy P Pearman; Jennifer L Beaumont; Diane Paul; Amy P Abernethy; Paul B Jacobsen; Karen L Syrjala; Jamie Von Roenn; David Cella Journal: J Pain Symptom Manage Date: 2012-09-25 Impact factor: 3.612
Authors: Iris Krebbers; Walmari Pilz; Sophie Vanbelle; Rob J C G Verdonschot; Laura W J Baijens Journal: Dysphagia Date: 2022-07-07 Impact factor: 3.438
Authors: Bryce B Reeve; Jianwen Cai; Hongtao Zhang; Jaeun Choi; Mark C Weissler; David Cella; Andrew F Olshan Journal: Head Neck Date: 2012-08-21 Impact factor: 3.147
Authors: Risa L Wong; Areej El-Jawahri; Sara M D'Arpino; Charn-Xin Fuh; P Connor Johnson; Daniel E Lage; Kelly E Irwin; William F Pirl; Lara Traeger; Barbara J Cashavelly; Vicki A Jackson; Joseph A Greer; David P Ryan; Ephraim P Hochberg; Jennifer S Temel; Ryan D Nipp Journal: Oncologist Date: 2018-08-06