Literature DB >> 21541534

Telomerase activity in human intestine.

E Hiyama1, N Tatsumoto, T Kodama, K Hiyama, J Shay, T Yokoyama.   

Abstract

In human somatic cells without the activity of telomerase, the ends of chromosomes consisting of the telomeric repeats TTAGGG progressively erode with each cell division. In germline and immortal cells telomerase activity maintains telomere length and thus compensates for the 'end-replication problem'. Progressive telomere shortening and reactivation of telomerase activity have been considered to be one of the key mechanisms in cellular senescence and immortalization. It has been shown that while most somatic cells do not have detectable telomerase activity, almost all cancers do have telomerase activity. Thus, detection of telomerase activity may have utility in the early diagnosis of cancer and may be a new target for therapeutic intervention. However, there is recent evidence that some cells of renewal tissues, such as hematopoietic cells and basal cells of the epidermis, have detectable telomerase activity. In the present study, we report detectable telomerase activity in normal human intestinal mucosa. This activity is localized to the lower third of each crypt and may be derived from intestinal stem cells. Since intestinal telomeric repeats are shorter in adults when compared to children, the telomerase activity in the intestine is insufficient to maintain telomere length but may be sufficient to provide extended proliferative capacity for such renewal tissues.

Entities:  

Year:  1996        PMID: 21541534     DOI: 10.3892/ijo.9.3.453

Source DB:  PubMed          Journal:  Int J Oncol        ISSN: 1019-6439            Impact factor:   5.650


  34 in total

1.  Functional requirement of p23 and Hsp90 in telomerase complexes.

Authors:  S E Holt; D L Aisner; J Baur; V M Tesmer; M Dy; M Ouellette; J B Trager; G B Morin; D O Toft; J W Shay; W E Wright; M A White
Journal:  Genes Dev       Date:  1999-04-01       Impact factor: 11.361

2.  A rapid, useful and quantitative method to measure telomerase activity by hybridization protection assay connected with a telomeric repeat amplification protocol.

Authors:  M Hirose; J Abe-Hashimoto; K Ogura; H Tahara; T Ide; T Yoshimura
Journal:  J Cancer Res Clin Oncol       Date:  1997       Impact factor: 4.553

3.  The induction of growth arrest in fibroblasts by SV40 T antigen.

Authors:  Xinwen Wang; Yuan Liu; Rui Dong; Yan Jin
Journal:  Mol Biol Rep       Date:  2006-09       Impact factor: 2.316

4.  Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues.

Authors:  E Hiyama; K Hiyama; T Yokoyama; J W Shay
Journal:  Neoplasia       Date:  2001 Jan-Feb       Impact factor: 5.715

5.  Lack of cell cycle regulation of telomerase activity in human cells.

Authors:  S E Holt; D L Aisner; J W Shay; W E Wright
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-30       Impact factor: 11.205

Review 6.  Telomerase activity, cell proliferation, and cancer.

Authors:  C W Greider
Journal:  Proc Natl Acad Sci U S A       Date:  1998-01-06       Impact factor: 11.205

7.  Telomere shortening with aging in human esophageal mucosa.

Authors:  K Takubo; K Nakamura; N Izumiyama; M Sawabe; T Arai; Y Esaki; Y Tanaka; K Mafune; M Fujiwara; M Kammori; K Sasajima
Journal:  Age (Omaha)       Date:  1999-07

8.  Telomere attrition occurs during ex vivo expansion of human dental pulp stem cells.

Authors:  Jaroslav Mokry; Tomas Soukup; Stanislav Micuda; Jana Karbanova; Benjamin Visek; Eva Brcakova; Jakub Suchanek; Jan Bouchal; Doris Vokurkova; Romana Ivancakova
Journal:  J Biomed Biotechnol       Date:  2010-10-04

9.  Telomerase expression in chickens: constitutive activity in somatic tissues and down-regulation in culture.

Authors:  R N Venkatesan; C Price
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-08       Impact factor: 11.205

10.  Telomere length assessment in leukocytes presents potential diagnostic value in patients with breast cancer.

Authors:  Wojciech Barczak; Natalia Rozwadowska; Aleksandra Romaniuk; Natalia Lipińska; Natalia Lisiak; Sylwia Grodecka-Gazdecka; Krzysztof Książek; Błażej Rubiś
Journal:  Oncol Lett       Date:  2016-02-04       Impact factor: 2.967

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.