Literature DB >> 21541531

Autocrine motility factor and its receptor expressions in human oral squamous cell carcinoma (SCC) cells.

Y Niinaka1, S Oida, A Ishisaki, K Takeda, T Iimura, Y Maruoka, F Momose, A Negishi, H Ichijo, T Amagasa, S Sasaki, H Watanabe, A Raz.   

Abstract

Autocrine motility factor (AMF) a tumor-secreted 55 kDa cytokine induces tumor cell motility by a signal transduction pathway mediated by interaction with its receptor (AMFR) a cell surface glycoprotein of 78 kDa (gp78). Here, AMF secreted by the metastatic LMF4 human oral squamous-cell carcinoma (SCC) cells, induced dose- and time-dependent morphological changes and chemotaxis of the producing cells. Expression of AMFR mRNA was associated with the metastatic ability of SCC cell variants. The data presented show for the first time that SCC cells produce AMF and express AMFR and the expression is related to their invasiveness and metastatic potentials.

Entities:  

Year:  1996        PMID： 21541531     DOI： 10.3892/ijo.9.3.433

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  6 in total

1.  Silencing of autocrine motility factor induces mesenchymal-to-epithelial transition and suppression of osteosarcoma pulmonary metastasis.

Authors:  Yasufumi Niinaka; Kiyoshi Harada; Masahiro Fujimuro; Masamitsu Oda; Arayo Haga; Misa Hosoki; Narikazu Uzawa; Naoya Arai; Satoshi Yamaguchi; Masashi Yamashiro; Avraham Raz
Journal:  Cancer Res       Date:  2010-10-26       Impact factor: 12.701

2.  Immunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic Tumours.

Authors:  Harshaminder Kaur Grewal; Sneha Sethi
Journal:  J Clin Diagn Res       Date:  2014-10-20

3.  Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1α and autophagy in human osteosarcoma.

Authors:  Yan Zhang; Ying Liu; Jilong Zou; Lixin Yan; Wei Du; Yafeng Zhang; Hanliang Sun; Peng Lu; Shuo Geng; Rui Gu; Hongyue Zhang; Zhenggang Bi
Journal:  Oncotarget       Date:  2017-08-03

4.  Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma.

Authors:  Shang-Lun Chiang; Bharath Kumar Velmurugan; Chia-Min Chung; Shu-Hui Lin; Zhi-Hong Wang; Chun-Hung Hua; Ming-Hsui Tsai; Tzer-Min Kuo; Kun-Tu Yeh; Pei-Ying Chang; Yi-Hsin Yang; Ying-Chin Ko
Journal:  Sci Rep       Date:  2017-07-24       Impact factor: 4.379

5.  A novel binding of GTP stabilizes the structure and modulates the activities of human phosphoglucose isomerase/autocrine motility factor.

Authors:  Hua-Yang Lin; Jyung-Hurng Liu; Ka-Lik Cheng; Jia-Yun Lin; Ni-Rung Liu; Menghsiao Meng
Journal:  Biochem Biophys Rep       Date:  2015-04-30

Review 6.  Gp78 E3 Ubiquitin Ligase: Essential Functions and Contributions in Proteostasis.

Authors:  Vibhuti Joshi; Arun Upadhyay; Amit Kumar; Amit Mishra
Journal:  Front Cell Neurosci       Date:  2017-08-25       Impact factor: 5.505
  6 in total

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