PKCs.

Molecular cloning and biochemical characterization of individual members of the protein kinase C (PKC) family demonstrated that single PKC isoenzymes display distinct structure, activation conditions, substrate specificity and tissue distribution. In the last few years a number of studies based on isoenzyme overexpression indicated that the PKC family coordinates a complex network of pivotal signal transduction pathways and pathway crosstalks, which regulate cell growth and differentiation, neoplastic transformation and malignant progression. This study reviews recent progress in PKC investigation, and focuses on achievements which have been shown to be relevant to cancer research.