Interkinetic nuclear migration: cell cycle on the move.

Interkinetic nuclear migration (INM) is a common feature of developing neuroepithelia, consisting of the periodic movement of the cell nucleus in phase with cell-cycle progression. In this issue of The EMBO Journal, Kosodo et al provide a first molecular mechanism to couple nuclear migration and cell cycle: the microtubule-associated protein Tpx2 redistributes from the nucleus to the apical process during the S-G2 transition, modulating microtubule organization to promote apical nuclear migration.