Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Transforming ER exit: protein secretion meets oncogenesis.

Literature DB >> 21540852

Transforming ER exit: protein secretion meets oncogenesis.

Abstract

COPII-coated vesicles drive protein export from the endoplasmic reticulum (ER), although the regulation of this event, both spatially and kinetically, remains unclear. TFG is now defined as a factor that modulates recruitment of the coat and links ER sequestration of kinases to oncogenesis.

Entities: Gene

Mesh：

Substances：
Proteins

Year: 2011 PMID： 21540852 DOI： 10.1038/ncb0511-525

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

14 in total

Review 1. Bi-directional protein transport between the ER and Golgi.

Authors: Marcus C S Lee; Elizabeth A Miller; Jonathan Goldberg; Lelio Orci; Randy Schekman
Journal: Annu Rev Cell Dev Biol Date: 2004 Impact factor: 13.827

2. Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization.

Authors: Dibyendu Bhattacharyya; Benjamin S Glick
Journal: Mol Biol Cell Date: 2006-12-27 Impact factor: 4.138

Review 3. New insights into the structural mechanisms of the COPII coat.

Authors: Christopher Russell; Scott M Stagg
Journal: Traffic Date: 2009-12-07 Impact factor: 6.215

4. Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER.

Authors: Helen Hughes; Annika Budnik; Katy Schmidt; Krysten J Palmer; Judith Mantell; Chris Noakes; Andrew Johnson; Deborah A Carter; Paul Verkade; Peter Watson; David J Stephens
Journal: J Cell Sci Date: 2009-07-28 Impact factor: 5.285

Review 5. Regulation of coat assembly--sorting things out at the ER.

Authors: Elizabeth A Miller; Charles Barlowe
Journal: Curr Opin Cell Biol Date: 2010-05-01 Impact factor: 8.382

6. TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations.

Authors: L Hernández; M Pinyol; S Hernández; S Beà; K Pulford; A Rosenwald; L Lamant; B Falini; G Ott; D Y Mason; G Delsol; E Campo
Journal: Blood Date: 1999-11-01 Impact factor: 22.113

Transforming ER exit: protein secretion meets oncogenesis.

Review 1. Bi-directional protein transport between the ER and Golgi.

2. Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization.

Review 3. New insights into the structural mechanisms of the COPII coat.

4. Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER.

Review 5. Regulation of coat assembly--sorting things out at the ER.

6. TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations.

7. Drosophila Sec16 mediates the biogenesis of tER sites upstream of Sar1 through an arginine-rich motif.

8. Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum.

9. TFG-1 function in protein secretion and oncogenesis.

10. Sec16p potentiates the action of COPII proteins to bud transport vesicles.

1. Deregulation of CLTC interacts with TFG, facilitating osteosarcoma via the TGF-beta and AKT/mTOR signaling pathways.