Literature DB >> 2154035

Expression of beta-nerve growth factor receptor mRNA in Sertoli cells downregulated by testosterone.

H Persson1, C Ayer-Le Lievre, O Söder, M J Villar, M Metsis, L Olson, M Ritzen, T Hökfelt.   

Abstract

Nerve growth factor (NGF) is synthesized in male germ cells. The NGF receptor (NGFR) mRNA was found in the Sertoli cells of rat testis. Hypophysectomy increased both NGFR mRNA in testis and the number of NGFR hybridizing cells in seminiferous tubules. This was suppressed by treatment with chorionic gonadotropin or testosterone, but not with follicle-stimulating hormone. The NGFR mRNA also increased after destruction of Leydig cells or blocking of the androgen receptor. This suggests that NGF produced by male germ cells regulates testicular function in an androgen-modulated fashion by mediating an interaction germ and Sertoli cells.

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Year:  1990        PMID： 2154035     DOI： 10.1126/science.2154035

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  21 in total

Review 1.  The thymic education of developing T cells in self neuroendocrine principles.

Authors:  V Geenen; F Robert; H Martens; D De Groote; P Franchimont
Journal:  J Endocrinol Invest       Date:  1992-09       Impact factor: 4.256

Review 2.  Growth factors and testis.

Authors:  G Giordano; P Del Monte; F Minuto
Journal:  J Endocrinol Invest       Date:  1992-01       Impact factor: 4.256

3.  Cellular localization of NGF and its receptors trkA and p75LNGFR in male reproductive organs of the Japanese monkey, Macaca fuscata fuscata.

Authors:  Wanzhu Jin; Koji Y Arai; Keiko Shimizu; Chihiro Kojima; Mariko Itoh; Gen Watanabe; Kazuyoshi Taya
Journal:  Endocrine       Date:  2006-02       Impact factor: 3.633

Review 4.  Paracrine factors and the regulation of spermatogenesis.

Authors:  C S Niederberger; S Shubhada; S J Kim; D J Lamb
Journal:  World J Urol       Date:  1993       Impact factor: 4.226

5.  Role of neurotrophins and neurotrophins receptors in the in vitro invasion and heparanase production of human prostate cancer cells.

Authors:  E T Walch; D Marchetti
Journal:  Clin Exp Metastasis       Date:  1999-06       Impact factor: 5.150

6.  Structure of human glutathione S-transferase class Mu genes.

Authors:  J B Taylor; J Oliver; R Sherrington; S E Pemble
Journal:  Biochem J       Date:  1991-03-01       Impact factor: 3.857

7.  Transcriptional repression of the alpha-subunit gene by androgen receptor occurs independently of DNA binding but requires the DNA-binding and ligand-binding domains of the receptor.

Authors:  L L Heckert; E M Wilson; J H Nilson
Journal:  Mol Endocrinol       Date:  1997-09

8.  Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: melanoma p75 functions independently of trkA.

Authors:  J L Herrmann; D G Menter; J Hamada; D Marchetti; M Nakajima; G L Nicolson
Journal:  Mol Biol Cell       Date:  1993-11       Impact factor: 4.138

9.  Effects of increased nerve growth factor plasma levels on the expression of TrkA and p75 in rat testicles.

Authors:  M B Levanti; A Germanà; F de Carlos; E Ciriaco; J A Vega; G Germanà
Journal:  J Anat       Date:  2006-03       Impact factor: 2.610

10.  An acceleration of age-related increases in levels of the beta-subunit of nerve growth factor in selected tissues from senescence-accelerated mice (SAM-P/8).

Authors:  R Katoh-Semba; R Semba; S Kashiwamata; K Kato
Journal:  J Mol Neurosci       Date:  1993       Impact factor: 3.444
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