Literature DB >> 2154034

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.

M J Sheardown1, E O Nielsen, A J Hansen, P Jacobsen, T Honoré.   

Abstract

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) is an analog of the quinoxalinedione antagonists to the non-N-methyl-D-aspartate (non-NMDA) glutamate receptor. NBQX is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine sites. NBQX protects against global ischemia, even when administered 2 hours after an ischemic challenge.

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Year:  1990        PMID： 2154034     DOI： 10.1126/science.2154034

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  136 in total

1.  Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats.

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2.  Excitatory amino acid neurotoxicity--a broader horizon for cerebral protection?

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Review 5.  Blockade of glutamate excitotoxicity and its clinical applications.

Authors:  K Hirose; P H Chan
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6.  ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma.

Authors:  L Turski; A Huth; M Sheardown; F McDonald; R Neuhaus; H H Schneider; U Dirnagl; F Wiegand; P Jacobsen; E Ottow
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

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8.  Ethanol differentially inhibits homoquinolinic acid- and NMDA-induced neurotoxicity in primary cultures of cerebellar granule cells.

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9.  Attenuation by chlormethiazole administration of the rise in extracellular amino acids following focal ischaemia in the cerebral cortex of the rat.

Authors:  H A Baldwin; J L Williams; M Snares; T Ferreira; A J Cross; A R Green
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10.  Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors.

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