| Literature DB >> 21539774 |
L B Dyksterhuis1, L D Dyksterhuis, J F White, M Hickey, N Kirby, S Mudie, A Hawley, A Vashi, J Nigro, J A Werkmeister, J A M Ramshaw.
Abstract
We assessed the importance of glycosaminoglycans and sulfur-mediated bonds for the mechanical properties of lens capsules by comparing the stress-strain responses from control and treated pairs of bovine source. No significant change in mechanical properties was observed upon reduction of disulfide bonds. However, removal of glycosaminoglycan chains resulted in a significantly stiffer lens capsule, whereas high concentrations of reducing agent, which is expected to reduce the recently reported sulfilimine bond of collagen IV, resulted in a significantly less stiff lens capsule. A comparison of the diffraction patterns of the control and strongly reduced lens capsules indicated structural rearrangements on a nanometer scale.Entities:
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Year: 2011 PMID： 21539774 PMCID： PMC3149272 DOI： 10.1016/j.bpj.2011.03.020
Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033