Literature DB >> 21539394

Turnagainolides A and B, cyclic depsipeptides produced in culture by a Bacillus sp.: isolation, structure elucidation, and synthesis.

Dehai Li1, Gavin Carr, Yonghong Zhang, David E Williams, Ashraf Amlani, Helen Bottriell, Alice L-F Mui, Raymond J Andersen.   

Abstract

Two new cyclic depsipeptides, turnagainolides A (1) and B (2), have been isolated from laboratory cultures of a marine isolate of Bacillus sp. The structures of 1 and 2, which are simply epimers at the site of macrolactonization, were elucidated by analysis of NMR data and chemical degradation. A total synthesis of the turnagainolides confirmed their structures. Turnagainolide B (2) showed activity in a SHIP1 activation assay.

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Year:  2011        PMID： 21539394     DOI： 10.1021/np200033y

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

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7.  Marine Microorganism-Derived Macrolactins Inhibit Inflammatory Mediator Effects in LPS-Induced Macrophage and Microglial Cells by Regulating BACH1 and HO-1/Nrf2 Signals through Inhibition of TLR4 Activation.

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Journal:  Molecules       Date:  2020-02-04       Impact factor: 4.411

Review 8.  Bacillus for Plant Growth Promotion and Stress Resilience: What Have We Learned?

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Review 9.  Diversity of secondary metabolites from marine Bacillus species: chemistry and biological activity.

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Journal:  Mar Drugs       Date:  2013-08-12       Impact factor: 5.118
  9 in total

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