Kai-Ming Yang1, Wang Yong, Ai-Dong Li, Hui-Jun Yang. 1. Kai-Ming Yang, Wang Yong, Department of Anatomy and His-tology and Embryology, Dali University, Dali 671000, Yunnan Province, China.
Abstract
AIM: To investigate the differentiation and migration of endocrine cells to form the pancreatic islets of Langer-hans in early human development. METHODS: Embryonic pancreas of 6-14 wk gestation was observed using immunocytochemistry methods in early human development. RESULTS: Insulin and glucagon are expressed in the same epithelium cells in the pancreas. In addition, in-sulin-producing cells also secrete somatostatin in early human embryonic development and these insulin-pro-ducing cells also express nestin. CONCLUSION: Pancreatic duct epithelial cells that can produce insulin in early human development are pre-cursors and still have the potential to differentiate other endocrine cells. These progenitors have differen-tiated before migration from primary ductal epithelium to form the pancreatic islets.
AIM: To investigate the differentiation and migration of endocrine cells to form the pancreatic islets of Langer-hans in early human development. METHODS:Embryonic pancreas of 6-14 wk gestation was observed using immunocytochemistry methods in early human development. RESULTS:Insulin and glucagon are expressed in the same epithelium cells in the pancreas. In addition, in-sulin-producing cells also secrete somatostatin in early human embryonic development and these insulin-pro-ducing cells also express nestin. CONCLUSION:Pancreatic duct epithelial cells that can produce insulin in early human development are pre-cursors and still have the potential to differentiate other endocrine cells. These progenitors have differen-tiated before migration from primary ductal epithelium to form the pancreatic islets.
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