AIMS: To examine the association of midlife report of crisis following parental death (CFPD) during childhood and adolescence, with dementia at old age. METHODS: In 1965, 9362 male participants of the Israel Ischemic Heart Disease study were asked whether they have experienced CFPD (paternal or maternal) during the following ages: 0 to 6, 7 to 12, 13 to 18, or >18 years. Dementia was assessed over 3 decades later in 1889 survivors of the original cohort, 1652 of whom were assessed for CFPD in 1965. RESULTS: Controlling for age, the estimated odds ratios for dementia relative to individuals who reported crisis following paternal parental death (CFPD-P) at the age of 18 years and above were 3.06 (95% CI: 1.42-6.61), 2.15 (95% CI: 0.87-5.31), and 2.35 (95% CI: 1.05-5.28) for those who reported CFPD-P at the ages of 0 to 6, 7 to 12, and 13 to 18 years, respectively. Odds ratios for dementia were 0.60 (95% CI: 0.32-1.11) for participants who reported CFPD-P at ages of 18 and above compared with participants who did not report such a crisis. Similar results were obtained for the association of crisis reported following maternal parental death (CFPD-M) at different age groups and dementia. CONCLUSIONS: CFPD during childhood is associated with an increased risk for dementia in men who survived until old age. (C) 2012 Lippincott Williams & Wilkins, Inc.
AIMS: To examine the association of midlife report of crisis following parental death (CFPD) during childhood and adolescence, with dementia at old age. METHODS: In 1965, 9362 male participants of the Israel Ischemic Heart Disease study were asked whether they have experienced CFPD (paternal or maternal) during the following ages: 0 to 6, 7 to 12, 13 to 18, or >18 years. Dementia was assessed over 3 decades later in 1889 survivors of the original cohort, 1652 of whom were assessed for CFPD in 1965. RESULTS: Controlling for age, the estimated odds ratios for dementia relative to individuals who reported crisis following paternal parental death (CFPD-P) at the age of 18 years and above were 3.06 (95% CI: 1.42-6.61), 2.15 (95% CI: 0.87-5.31), and 2.35 (95% CI: 1.05-5.28) for those who reported CFPD-P at the ages of 0 to 6, 7 to 12, and 13 to 18 years, respectively. Odds ratios for dementia were 0.60 (95% CI: 0.32-1.11) for participants who reported CFPD-P at ages of 18 and above compared with participants who did not report such a crisis. Similar results were obtained for the association of crisis reported following maternal parental death (CFPD-M) at different age groups and dementia. CONCLUSIONS:CFPD during childhood is associated with an increased risk for dementia in men who survived until old age. (C) 2012 Lippincott Williams & Wilkins, Inc.
Authors: Julie Cerel; Mary A Fristad; Joseph Verducci; Ronald A Weller; Elizabeth B Weller Journal: J Am Acad Child Adolesc Psychiatry Date: 2006-06 Impact factor: 8.829
Authors: Michal Schnaider Beeri; Michael Davidson; Jeremy M Silverman; Shlomo Noy; James Schmeidler; Uri Goldbourt Journal: Am J Geriatr Psychiatry Date: 2005-02 Impact factor: 4.105
Authors: Maria C Norton; Elizabeth Fauth; Christine J Clark; Dan Hatch; Daylee Greene; Roxane Pfister; JoAnn T Tschanz; Ken R Smith Journal: Int J Geriatr Psychiatry Date: 2015-07-01 Impact factor: 3.485
Authors: S Bachiller; I Hidalgo; M G Garcia; A Boza-Serrano; A Paulus; Q Denis; C Haikal; O Manouchehrian; O Klementieva; J Y Li; C J Pronk; G K Gouras; T Deierborg Journal: J Neuroinflammation Date: 2022-06-15 Impact factor: 9.587
Authors: Sylvie L Lesuis; Lianne Hoeijmakers; Aniko Korosi; Susanne R de Rooij; Dick F Swaab; Helmut W Kessels; Paul J Lucassen; Harm J Krugers Journal: Alzheimers Res Ther Date: 2018-09-19 Impact factor: 6.982