Literature DB >> 21536730

Addicted to Myc--but why?

Björn von Eyss1, Martin Eilers.   

Abstract

Many tumors continuously depend on the initiating oncogenes, but whether this extends to their downstream targets is unclear. In this issue of Genes & Development, Sodir and colleagues (pp. 907-916) demonstrate an essential role for endogenous Myc proteins in maintaining the tumor microenvironment, providing an unexpected molecular explanation for addiction to Myc.

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Year:  2011        PMID： 21536730      PMCID： PMC3084022          DOI： 10.1101/gad.2053311

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  20 in total

1.  Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism.

Authors:  David N Boone; Ying Qi; Zhaoliang Li; Stephen R Hann
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-27       Impact factor: 11.205

2.  CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation.

Authors:  Kavya Rakhra; Pavan Bachireddy; Tahera Zabuawala; Robert Zeiser; Liwen Xu; Andrew Kopelman; Alice C Fan; Qiwei Yang; Lior Braunstein; Erika Crosby; Sandra Ryeom; Dean W Felsher
Journal:  Cancer Cell       Date:  2010-10-28       Impact factor: 31.743

3.  Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model.

Authors:  Jason T Yustein; Yen-Chun Liu; Ping Gao; Chunfa Jie; Anne Le; Milena Vuica-Ross; Wee Joo Chng; Charles G Eberhart; P Leif Bergsagel; Chi V Dang
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-02       Impact factor: 11.205

4.  The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis.

Authors:  Barbara Herkert; Anne Dwertmann; Steffi Herold; Mona Abed; Jean-Francois Naud; Florian Finkernagel; Gregory S Harms; Amir Orian; Michael Wanzel; Martin Eilers
Journal:  J Cell Biol       Date:  2010-03-22       Impact factor: 10.539

5.  Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity.

Authors:  Elisa Laurenti; Barbara Varnum-Finney; Anne Wilson; Isabel Ferrero; William E Blanco-Bose; Armin Ehninger; Paul S Knoepfler; Pei-Feng Cheng; H Robson MacDonald; Robert N Eisenman; Irwin D Bernstein; Andreas Trumpp
Journal:  Cell Stem Cell       Date:  2008-12-04       Impact factor: 24.633

6.  Principles of cancer therapy: oncogene and non-oncogene addiction.

Authors:  Ji Luo; Nicole L Solimini; Stephen J Elledge
Journal:  Cell       Date:  2009-03-06       Impact factor: 41.582

7.  A positive role for Myc in TGFbeta-induced Snail transcription and epithelial-to-mesenchymal transition.

Authors:  A P Smith; A Verrecchia; G Fagà; M Doni; D Perna; F Martinato; E Guccione; B Amati
Journal:  Oncogene       Date:  2008-11-03       Impact factor: 9.867

8.  Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.

Authors:  Maria Barna; Aya Pusic; Ornella Zollo; Maria Costa; Nadya Kondrashov; Eduardo Rego; Pulivarthi H Rao; Davide Ruggero
Journal:  Nature       Date:  2008-11-16       Impact factor: 49.962

9.  Myc deletion rescues Apc deficiency in the small intestine.

Authors:  Owen J Sansom; Valerie S Meniel; Vanesa Muncan; Toby J Phesse; Julie A Wilkins; Karen R Reed; J Keith Vass; Dimitris Athineos; Hans Clevers; Alan R Clarke
Journal:  Nature       Date:  2007-03-21       Impact factor: 49.962

Review 10.  HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation.

Authors:  John D Gordan; Craig B Thompson; M Celeste Simon
Journal:  Cancer Cell       Date:  2007-08       Impact factor: 31.743
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  7 in total

1.  Perturbation of the c-Myc-Max protein-protein interaction via synthetic α-helix mimetics.

Authors:  Kwan-Young Jung; Huabo Wang; Peter Teriete; Jeremy L Yap; Lijia Chen; Maryanna E Lanning; Angela Hu; Lester J Lambert; Toril Holien; Anders Sundan; Nicholas D P Cosford; Edward V Prochownik; Steven Fletcher
Journal:  J Med Chem       Date:  2015-03-30       Impact factor: 7.446

2.  A cell engineering strategy to enhance the safety of stem cell therapies.

Authors:  Elisa Oricchio; Eirini P Papapetrou; Fabien Lafaille; Yosif M Ganat; Sonja Kriks; Ana Ortega-Molina; Willie H Mark; Julie Teruya-Feldstein; Jason T Huse; Victor Reuter; Michel Sadelain; Lorenz Studer; Hans-Guido Wendel
Journal:  Cell Rep       Date:  2014-09-18       Impact factor: 9.423

3.  Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy.

Authors:  Marie-Eve Beaulieu; Toni Jauset; Daniel Massó-Vallés; Sandra Martínez-Martín; Peter Rahl; Loïka Maltais; Mariano F Zacarias-Fluck; Sílvia Casacuberta-Serra; Erika Serrano Del Pozo; Christopher Fiore; Laia Foradada; Virginia Castillo Cano; Meritxell Sánchez-Hervás; Matthew Guenther; Eduardo Romero Sanz; Marta Oteo; Cynthia Tremblay; Génesis Martín; Danny Letourneau; Martin Montagne; Miguel Ángel Morcillo Alonso; Jonathan R Whitfield; Pierre Lavigne; Laura Soucek
Journal:  Sci Transl Med       Date:  2019-03-20       Impact factor: 17.956

4.  The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy.

Authors:  Mauro Savino; Daniela Annibali; Nicoletta Carucci; Emilia Favuzzi; Michael D Cole; Gerard I Evan; Laura Soucek; Sergio Nasi
Journal:  PLoS One       Date:  2011-07-21       Impact factor: 3.240

5.  Site-specific amino acid substitution in dodecameric peptides determines the stability and unfolding of c-MYC quadruplex promoting apoptosis in cancer cells.

Authors:  Pallabi Sengupta; Nilanjan Banerjee; Tanaya Roychowdhury; Anindya Dutta; Samit Chattopadhyay; Subhrangsu Chatterjee
Journal:  Nucleic Acids Res       Date:  2018-11-02       Impact factor: 16.971

6.  MYC protein stability is negatively regulated by BRD4.

Authors:  Ballachanda N Devaiah; Jie Mu; Ben Akman; Sheetal Uppal; Jocelyn D Weissman; Dan Cheng; Laura Baranello; Zuqin Nie; David Levens; Dinah S Singer
Journal:  Proc Natl Acad Sci U S A       Date:  2020-06-01       Impact factor: 11.205

Review 7.  Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc.

Authors:  Daniel Massó-Vallés; Laura Soucek
Journal:  Cells       Date:  2020-04-04       Impact factor: 6.600
  7 in total

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