Literature DB >> 2153579

Mastoparan inhibits phosphoinositide hydrolysis via pertussis toxin-insensitive [corrected] G-protein in human astrocytoma cells.

N Nakahata1, M T Abe, I Matsuoka, H Nakanishi.   

Abstract

Mastoparan inhibited [3H]inositol phosphate accumulation induced by carbachol as well as cyclic AMP accumulation induced by isoproterenol in 1321N1 human astrocytoma cells. Mastoparan inhibited GTP gamma S-induced, but not Ca2(+)-induced, [3H]inositol phosphate accumulation in membrane preparations with an IC50 of approximately 10 microM. The inhibitory effect of mastoparan on carbachol-induced [3H]inositol phosphate accumulation was resistant to pertussis toxin (IAP) treatment in intact cells. These results suggest that mastoparan inhibits phospholipase C in human astrocytoma cells via a GTP binding protein, which is not a substrate for IAP.

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Year:  1990        PMID： 2153579     DOI： 10.1016/0014-5793(90)80074-s

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

Review 1.  Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors.

Authors:  S Cockcroft; G M Thomas
Journal:  Biochem J       Date:  1992-11-15       Impact factor: 3.857

2.  Characterization of a mastoparan-stimulated nucleotidase from bovine brain.

Authors:  B M Denker; P Tempst; E J Neer
Journal:  Biochem J       Date:  1991-09-01       Impact factor: 3.857

3.  Dual effects of mastoparan on intracellular free Ca2+ concentrations in human astrocytoma cells.

Authors:  N Nakahata; H Ishimoto; K Mizuno; Y Ohizumi; H Nakanishi
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

4.  Mastoparan-induced phosphatidylcholine hydrolysis by phospholipase D activation in human astrocytoma cells.

Authors:  K Mizuno; N Nakahata; Y Ohizumi
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

5.  Activation of Gi induces mechanical hyperalgesia poststress or inflammation.

Authors:  O A Dina; S G Khasar; R W Gear; J D Levine
Journal:  Neuroscience       Date:  2009-03-09       Impact factor: 3.590

6.  Mastoparan may activate GTP hydrolysis by Gi-proteins in HL-60 membranes indirectly through interaction with nucleoside diphosphate kinase.

Authors:  J F Klinker; A Hagelüken; L Grünbaum; I Heilmann; B Nürnberg; R Harhammer; S Offermanns; I Schwaner; J Ervens; K Wenzel-Seifert
Journal:  Biochem J       Date:  1994-12-01       Impact factor: 3.857

7.  Mastoparan binds to glycogen phosphorylase to regulate sarcoplasmic reticular Ca2+ release in skeletal muscle.

Authors:  Yutaka Hirata; Masanori Atsumi; Yasushi Ohizumi; Norimichi Nakahata
Journal:  Biochem J       Date:  2003-04-01       Impact factor: 3.857

8.  Effects of the amphiphilic peptides mastoparan and adenoregulin on receptor binding, G proteins, phosphoinositide breakdown, cyclic AMP generation, and calcium influx.

Authors:  Y Shin; R W Moni; J E Lueders; J W Daly
Journal:  Cell Mol Neurobiol       Date:  1994-04       Impact factor: 5.046

9.  Mastoparan promotes exocytosis and increases intracellular cyclic AMP in human platelets. Evidence for the existence of a Ge-like mechanism of secretion.

Authors:  C P Wheeler-Jones; T Saermark; V V Kakkar; K S Authi
Journal:  Biochem J       Date:  1992-01-15       Impact factor: 3.857

Review 10.  Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: melittin, apamin and mastoparan.

Authors:  Miguel Moreno; Ernest Giralt
Journal:  Toxins (Basel)       Date:  2015-04-01       Impact factor: 4.546
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