Literature DB >> 2153553

Changes in the number of mitochondrial genomes during human development.

B G Heerdt1, L H Augenlicht.   

Abstract

Using a cDNA probe for the mitochondrially encoded third subunit of cytochrome c oxidase (COIII) we found a progressive increase in the number of mitochondrial DNA molecules in specific human tissues during normal fetal development. The data indicate that the tissue, rather than the final number of mitochondrial genomes, apparently plays a dominant role in determining the gestational stage at which the adult complement of this DNA is established.

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Year:  1990        PMID： 2153553     DOI： 10.1016/0014-4827(90)90209-s

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  2 in total

1.  An upstream open reading frame and the context of the two AUG codons affect the abundance of mitochondrial and nuclear RNase H1.

Authors:  Yutaka Suzuki; J Bradley Holmes; Susana M Cerritelli; Kiran Sakhuja; Michal Minczuk; Ian J Holt; Robert J Crouch
Journal:  Mol Cell Biol       Date:  2010-09-07       Impact factor: 4.272

2.  Simultaneous A8344G heteroplasmy and mitochondrial DNA copy number quantification in myoclonus epilepsy and ragged-red fibers (MERRF) syndrome by a multiplex molecular beacon based real-time fluorescence PCR.

Authors:  K Szuhai; J Ouweland; R Dirks; M Lemaître; J Truffert; G Janssen; H Tanke; E Holme; J Maassen; A Raap
Journal:  Nucleic Acids Res       Date:  2001-02-01       Impact factor: 16.971
  2 in total

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