BACKGROUND: Puberty is characterized by increases in growth hormone (GH) and insulin-like growth factor-1 (IGF-1) and the pubertal growth spurt. Bone formation and resorption also increase, consistent with increased bone metabolism. OBJECTIVE: To determine the relationship between pubertal bone metabolism, GH and IGF-1. We hypothesized that bone turnover peaks at the time of greatest pubertal GH secretion. DESIGN AND SUBJECTS: Subjects included 86 girls and boys, 9-17 years-old (BMI 10th-90th percentiles). Because higher endogenous GH secretion is associated with a higher nadir following oral glucose, we used the GH nadir following a 2-h OGTT as indicative of GH status. Fasting serum IGF-1, aminoterminal propeptide of type 1 procollagen (P1NP) and carboxy-terminal collagen crosslinks (CTX) were obtained. Subjects were grouped per expected timing of peak growth. Group 1: Tanner 1 girls and Tanner 1-2 boys (period preceding peak growth), Group 2: Tanner 2-3 girls and Tanner 3-4 boys (period of peak growth) and Group 3: Tanner 4-5 girls and Tanner 5 boys (period following peak growth). RESULTS: GH peaked at mid-puberty (Group 2) and IGF-1 in late puberty (Group 3). P1NP and CTX were highest in mid-puberty compared with early and late puberty (P = 0·0009 and 0·006 in girls and P = 0·005 and 0·04 in boys). GH, but not IGF-1, correlated with P1NP (r = 0·46 in both genders, P ≤ 0·008) and CTX (r = 0·37 and 0·38, P = 0·04 and 0·02 in girls and boys, respectively). Similarly, on regression modelling, GH (but not IGF-1) predicted both bone turnover markers in both genders. CONCLUSION: GH is strongly associated with pubertal bone metabolism, independent of systemic IGF-1 in girls and boys.
BACKGROUND: Puberty is characterized by increases in growth hormone (GH) and insulin-like growth factor-1 (IGF-1) and the pubertal growth spurt. Bone formation and resorption also increase, consistent with increased bone metabolism. OBJECTIVE: To determine the relationship between pubertal bone metabolism, GH and IGF-1. We hypothesized that bone turnover peaks at the time of greatest pubertal GH secretion. DESIGN AND SUBJECTS: Subjects included 86 girls and boys, 9-17 years-old (BMI 10th-90th percentiles). Because higher endogenous GH secretion is associated with a higher nadir following oral glucose, we used the GHnadir following a 2-h OGTT as indicative of GH status. Fasting serum IGF-1, aminoterminal propeptide of type 1 procollagen (P1NP) and carboxy-terminal collagen crosslinks (CTX) were obtained. Subjects were grouped per expected timing of peak growth. Group 1: Tanner 1 girls and Tanner 1-2 boys (period preceding peak growth), Group 2: Tanner 2-3 girls and Tanner 3-4 boys (period of peak growth) and Group 3: Tanner 4-5 girls and Tanner 5 boys (period following peak growth). RESULTS:GH peaked at mid-puberty (Group 2) and IGF-1 in late puberty (Group 3). P1NP and CTX were highest in mid-puberty compared with early and late puberty (P = 0·0009 and 0·006 in girls and P = 0·005 and 0·04 in boys). GH, but not IGF-1, correlated with P1NP (r = 0·46 in both genders, P ≤ 0·008) and CTX (r = 0·37 and 0·38, P = 0·04 and 0·02 in girls and boys, respectively). Similarly, on regression modelling, GH (but not IGF-1) predicted both bone turnover markers in both genders. CONCLUSION:GH is strongly associated with pubertal bone metabolism, independent of systemic IGF-1 in girls and boys.
Authors: S R Rose; G Municchi; K M Barnes; G A Kamp; M M Uriarte; J L Ross; F Cassorla; G B Cutler Journal: J Clin Endocrinol Metab Date: 1991-08 Impact factor: 5.958
Authors: Inge M van der Sluis; Wim C Hop; Johannes P T M van Leeuwen; Huib A P Pols; Sabine M P F de Muinck Keizer-Schrama Journal: Horm Res Date: 2002
Authors: A Blumsohn; R A Hannon; R Wrate; J Barton; A W al-Dehaimi; A Colwell; R Eastell Journal: Clin Endocrinol (Oxf) Date: 1994-05 Impact factor: 3.478
Authors: Catherine C Cohen; Eduardo Castillo-Leon; Alton B Farris; Shelley A Caltharp; Rebecca L Cleeton; Elizabeth M Sinclair; Diane E Shevell; Morten A Karsdal; Mette Juul Fisker Nielsen; Diana J Leeming; Miriam B Vos Journal: Hepatol Commun Date: 2021-07-08