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Literature DB >> 21534547

Highly potent activity of (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in animal models of Parkinson's disease.

Oleg V Ardashov¹, Alla V Pavlova, Irina V Il'ina, Ekaterina A Morozova, Dina V Korchagina, Elena V Karpova, Konstantin P Volcho, Tat'yana G Tolstikova, Nariman F Salakhutdinov.

Abstract

(1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 possesses potent antiparkinsonian activity in both MPTP and haloperidol animal models. The use of compound 1 resulted in nearly full recovery of the locomotor and exploratory activities and was as effective as the comparator agent (levodopa). All eight stereoisomers of compound 1 have been synthesized and the influence of the absolute configuration on the antiparkinsonian activity of compound 1 was shown.

Entities: Chemical Disease Gene

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Year: 2011 PMID： 21534547 DOI： 10.1021/jm2001579

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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Cited

7 in total

1. Using (+)-Carvone to access novel derivatives of (+)-ent-Cannabidiol: the first asymmetric syntheses of (+)-ent-CBDP and (+)-ent-CBDV.

Authors: Alexandra E Golliher; Antonio J Tenorio; Nina O Dimauro; Nicolas R Mairata; F Omar Holguin; William Maio
Journal: Tetrahedron Lett Date: 2021-02-05 Impact factor: 2.415

Highly potent activity of (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in animal models of Parkinson's disease.

1. Using (+)-Carvone to access novel derivatives of (+)-ent-Cannabidiol: the first asymmetric syntheses of (+)-ent-CBDP and (+)-ent-CBDV.

2. Selective Preparation of trans-Carveol over Ceria Supported Mesoporous Materials MCM-41 and SBA-15.

3. Stereoselective Synthesis and Investigation of Isopulegol-Based Chiral Ligands.

4. Effects of Immediate Aversive Stimulation on Haloperidol-Induced Catalepsy in Rats.

5. Stereoselective synthesis and application of isopulegol-based bi- and trifunctional chiral compounds.

6. Sub-synaptic localization of Ca_v3.1 T-type calcium channels in the thalamus of normal and parkinsonian monkeys.

7. Stereoselective Syntheses and Application of Chiral Bi- and Tridentate Ligands Derived from (+)-Sabinol.